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Mark Topazian, Michael Camilleri, Felicity T. Enders, Jonathan E

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Presentation on theme: "Mark Topazian, Michael Camilleri, Felicity T. Enders, Jonathan E"— Presentation transcript:

1 Gastric Antral Injections of Botulinum Toxin Delay Gastric Emptying but Do Not Reduce Body Weight 
Mark Topazian, Michael Camilleri, Felicity T. Enders, Jonathan E. Clain, Ferga C. Gleeson, Michael J. Levy, Elizabeth Rajan, Vandana Nehra, Ross A. Dierkhising, Maria L. Collazo–Clavell, Nicholas J. Talley, Matthew M. Clark  Clinical Gastroenterology and Hepatology  Volume 11, Issue 2, Pages e1 (February 2013) DOI: /j.cgh Copyright © 2013 AGA Institute Terms and Conditions

2 Figure 1 Change in GES T12 two weeks after gastric injections. Shaded boxes indicate the interquartile range; the lines and diamonds inside the boxes indicate median and mean values, respectively. P = .24, .04, and .24 for comparison of the 100-U, 300-U, and 500-U groups with placebo, respectively; overall P = .23. Clinical Gastroenterology and Hepatology  , e1DOI: ( /j.cgh ) Copyright © 2013 AGA Institute Terms and Conditions

3 Figure 2 Change (compared with baseline) in MTV 2 and 16 weeks after gastric injections. Shaded boxes indicate the interquartile range; the lines and diamonds inside the boxes indicate median and mean values, respectively, with outliers represented by open circles. There are no statistically significant differences between groups at either week 2 or week 16. Clinical Gastroenterology and Hepatology  , e1DOI: ( /j.cgh ) Copyright © 2013 AGA Institute Terms and Conditions

4 Figure 3 Body weight change after gastric injections. Lines represent mean body weight change over time for each treatment group. There are no statistically significant differences between groups at any time point. Clinical Gastroenterology and Hepatology  , e1DOI: ( /j.cgh ) Copyright © 2013 AGA Institute Terms and Conditions

5 Figure 4 GSRS scores over time. There are no statistically significant differences between groups at any time point. Clinical Gastroenterology and Hepatology  , e1DOI: ( /j.cgh ) Copyright © 2013 AGA Institute Terms and Conditions

6 Supplementary Figure 1 Study flow diagram.
Clinical Gastroenterology and Hepatology  , e1DOI: ( /j.cgh ) Copyright © 2013 AGA Institute Terms and Conditions


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