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On Modeling Human Leukocyte Antigen–Identical Sibling Match Probability for Allogeneic Hematopoietic Cell Transplantation: Estimating the Need for an.

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Presentation on theme: "On Modeling Human Leukocyte Antigen–Identical Sibling Match Probability for Allogeneic Hematopoietic Cell Transplantation: Estimating the Need for an."— Presentation transcript:

1 On Modeling Human Leukocyte Antigen–Identical Sibling Match Probability for Allogeneic Hematopoietic Cell Transplantation: Estimating the Need for an Unrelated Donor Source  Kelsey Besse, Martin Maiers, Dennis Confer, Mark Albrecht  Biology of Blood and Marrow Transplantation  Volume 22, Issue 3, Pages (March 2016) DOI: /j.bbmt Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Total fertility rate (TFR) conditional on maternal age, race, and year obtained from National Vital Statistics Reports via the National Center for Health Statistics [8,9]. Partial components of fertility rate are scaled 1000-fold and multiplied by the age interval (ie, 1000 ∗ πa,r,y ∗ Δa) to align their units with those of TFR. Gaps in year coverage represent unequal data collection periods for different maternal race and ethnic groups. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Probability of sibling survival conditional on age and race/ethnicity. Obtained from the National Center for Health Statistic's National Vital Statistics Reports-US Life Tables, 2008 [37]. These figures are calculated using American Community Survey population estimates by age and death certificate information relayed to the National Center for Health Statistics through the National Vital Statistics System. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 (A) Expected number of siblings versus patient age by race/ethnicity. (B) Sibling match probability versus patient age by race/ethnicity. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

5 Figure 4 Density of HCT utilization between 2011 and 2013 versus patient age and race/ethnicity (Center for International Blood and Marrow Transplant Research statistics). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions


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