1. Flow chart
Settergren M, et al. Eur Heart J [Epub ahead of print]

2. Baseline characteristics
Settergren M, et al. Eur Heart J [Epub ahead of print]

3. Lipids, inflammatory markers, and endothelin-1 at baseline and follow-up
Settergren M, et al. Eur Heart J [Epub ahead of print]

4. Absolute changes in flow-mediated endothelium dependent vasodilatation in the E10/S10 and S80 group from baseline to follow-up
Data are depicted as medians and quartiles; n = 18 in the E10/S10 group and n = 16 in the S80 group
Settergren M, et al. Eur Heart J [Epub ahead of print]

5. Effect of intra-arterial infusion of acetylcholine on forearm blood flow (FBF) before and during co-administration of the ETA receptor antagonist BQ123 and the ETB receptor antagonists BQ788 at baseline and at follow-up in the E10/S10 and S80 group
Data are presented as median and quartiles; n = 19 in all groups. The two groups did not differ with regard to their effect on the improvement in endotheliumdependent vasodilatation induced by endothelin receptor blockade (P = 0.66)
Settergren M, et al. Eur Heart J [Epub ahead of print]