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Deletion of GOLGA2P3Y but not GOLGA2P2Y is a risk factor for oligozoospermia  Sanjukta Sen, Rupesh Agarwal, Prafulla Ambulkar, Indira Hinduja, Kusum Zaveri,

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Presentation on theme: "Deletion of GOLGA2P3Y but not GOLGA2P2Y is a risk factor for oligozoospermia  Sanjukta Sen, Rupesh Agarwal, Prafulla Ambulkar, Indira Hinduja, Kusum Zaveri,"— Presentation transcript:

1 Deletion of GOLGA2P3Y but not GOLGA2P2Y is a risk factor for oligozoospermia 
Sanjukta Sen, Rupesh Agarwal, Prafulla Ambulkar, Indira Hinduja, Kusum Zaveri, Jyotsna Gokral, Asoke Pal, Deepak Modi  Reproductive BioMedicine Online  Volume 32, Issue 2, Pages (February 2016) DOI: /j.rbmo Copyright © 2015 Reproductive Healthcare Ltd. Terms and Conditions

2 Figure 1 Association of deletions of GOLGA2LY copies with oligozoospermia. (A) Polymerase chain reaction restriction fragment length polymorphism for the detection of GOLGA2LY copy deletion. Lane 1: 100 bp ladder, Lane 2, 3: GOLGA2P3Y deletion, Lane 4: GOLGA2P2Y deletion, Lane 5: female control, Lane 6: water control, Lane 7: no deletion, Lane 8: undigested DNA. Reproductive BioMedicine Online  , DOI: ( /j.rbmo ) Copyright © 2015 Reproductive Healthcare Ltd. Terms and Conditions

3 Figure 2 Effect of GOLGA2LY gene copy deletions on sperm concentration and motility. (A) sperm concentration (million/ml); and (B) motility (percentage motile sperm) in men with and without GOLGA2P2Y and GOLGA2P3Y irrespective of gr/gr rearrangements; (C) and (D) are sperm concentration and motility in men with gr/gr rearrangements. No deletion = without GOLGA2LY copy deletions and gr/gr rearrangements, n are the number of men assessed in each group. Data are expressed as mean and 95% CI. *, values statistically significant (P < 0.05) compared with no deletion group. Reproductive BioMedicine Online  , DOI: ( /j.rbmo ) Copyright © 2015 Reproductive Healthcare Ltd. Terms and Conditions


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