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Cannabinoid Reduces Inflammatory Cytokines, Tumor Necrosis Factor-α, and Type I Interferons in Dermatomyositis In Vitro  Elizabeth S. Robinson, Paul Alves,

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Presentation on theme: "Cannabinoid Reduces Inflammatory Cytokines, Tumor Necrosis Factor-α, and Type I Interferons in Dermatomyositis In Vitro  Elizabeth S. Robinson, Paul Alves,"— Presentation transcript:

1 Cannabinoid Reduces Inflammatory Cytokines, Tumor Necrosis Factor-α, and Type I Interferons in Dermatomyositis In Vitro  Elizabeth S. Robinson, Paul Alves, Muhammad M. Bashir, Majid Zeidi, Rui Feng, Victoria P. Werth  Journal of Investigative Dermatology  Volume 137, Issue 11, Pages (November 2017) DOI: /j.jid Copyright © 2017 The Authors Terms and Conditions

2 Figure 1 Ajulemic acid suppressed TNF-α, IFN-α, and IFN-β production from peripheral blood mononuclear cells of dermatomyositis patients. (a) Ln(TNFα), (b) ln(IFN-α), and (c) ln(IFN-β) secretion from peripheral blood mononuclear cells of dermatomyositis subjects treated with 0, 3, 10, and 15 μmol/L ajulemic acid. Line represents the mean. AJA, ajulemic acid; M, mol/L; TNF-α, tumor necrosis factor-α. Journal of Investigative Dermatology  , DOI: ( /j.jid ) Copyright © 2017 The Authors Terms and Conditions

3 Figure 2 IFN-α secretion was reduced in the peripheral blood mononuclear cells of subjects taking antimalarial medications. Ln(IFN-α) secretion from peripheral blood mononuclear cells of dermatomyositis subjects receiving antimalarial medications and dermatomyositis subjects not taking antimalarial medications. Line represents the mean. Journal of Investigative Dermatology  , DOI: ( /j.jid ) Copyright © 2017 The Authors Terms and Conditions


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