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Hepatitis B core-related antigen (HBcrAg) levels in the natural history of hepatitis B virus infection in a large European cohort predominantly infected.

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Presentation on theme: "Hepatitis B core-related antigen (HBcrAg) levels in the natural history of hepatitis B virus infection in a large European cohort predominantly infected."— Presentation transcript:

1 Hepatitis B core-related antigen (HBcrAg) levels in the natural history of hepatitis B virus infection in a large European cohort predominantly infected with genotypes A and D  B. Maasoumy, S.B. Wiegand, J. Jaroszewicz, B. Bremer, P. Lehmann, K. Deterding, A. Taranta, M.P. Manns, H. Wedemeyer, D. Glebe, M. Cornberg  Clinical Microbiology and Infection  Volume 21, Issue 6, Pages 606.e1-606.e10 (June 2015) DOI: /j.cmi Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

2 Fig. 1 Hepatitis B core-related antigen (HBcrAg) levels in the different phases of chronic hepatitis B virus (HBV) infection: hepatitis B e antigen (HBeAg)-positive immune tolerance (IT) phase, HBeAg-positive immune clearance (IC) phase, HBeAg-negative hepatitis (ENH) and HBeAg-negative inactive/quiescent carrier phase (ENQ). (a) Individual HBcrAg levels in each phase with mean and standard deviation (*p < 0.05; ****p < 0.0001). (b) Proportion of patient HBcrAg levels within certain ranges. (c) IC, ENH and ENQ divided by the present HBV genotype (GT) A or D. Clinical Microbiology and Infection  , 606.e1-606.e10DOI: ( /j.cmi ) Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

3 Fig. 2 Correlation between hepatitis B core-related antigen (HBcrAg) and hepatitis B virus (HBV) DNA serum levels in the different phases of HBV infection (a) and further divided by the present HBV genotype (GT) A or D (b). r, Spearman's correlation; r2, linear regression. Clinical Microbiology and Infection  , 606.e1-606.e10DOI: ( /j.cmi ) Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

4 Fig. 3 Correlation between hepatitis B core-related antigen (HBcrAg) and hepatitis B surface antigen (HBsAg) serum levels in the different phases of hepatitis B virus (HBV) infection (a) and further divided by present HBV genotype (GT) A or D (b). r, Spearman's correlation; r2, linear regression. Clinical Microbiology and Infection  , 606.e1-606.e10DOI: ( /j.cmi ) Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

5 Clinical Microbiology and Infection 2015 21, 606. e1-606. e10DOI: (10
Clinical Microbiology and Infection  , 606.e1-606.e10DOI: ( /j.cmi ) Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

6 Clinical Microbiology and Infection 2015 21, 606. e1-606. e10DOI: (10
Clinical Microbiology and Infection  , 606.e1-606.e10DOI: ( /j.cmi ) Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

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