1. Volume 141, Issue 5, Pages 1638-1647.e7 (November 2011)
Pharmacogenetic Trial of a Cannabinoid Agonist Shows Reduced Fasting Colonic Motility in Patients With Nonconstipated Irritable Bowel Syndrome 
Banny S. Wong, Michael Camilleri, Irene Busciglio, Paula Carlson, Lawrence A. Szarka, Duane Burton, Alan R. Zinsmeister 
Gastroenterology 
Volume 141, Issue 5, Pages e7 (November 2011)
DOI: /j.gastro
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2. Supplementary Figure 1
Trial flow chart and baseline characteristics of study participants (mean ± standard error of mean, unless otherwise noted).
Gastroenterology  , e7DOI: ( /j.gastro )
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3. Supplementary Figure 2
Experimental protocol. Stepwise distension during ascending method of limits was used to appraise thresholds and compliance, and random-order phasic distensions to obtain sensory ratings. Motor function was tested before drug, after drug, and after meal ingestion.
Gastroenterology  , e7DOI: ( /j.gastro )
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4. Figure 1
Effect of dronabinol on colonic compliance. The error bars are based on the square root of the ratio: pooled estimate of residual error variance (across all subgroups from the analysis of covariance) divided by the subgroup sample size.
Gastroenterology  , e7DOI: ( /j.gastro )
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5. Figure 2
Effect of dronabinol on colonic phasic pressure activity. The error bars are based on the square root of the ratio: pooled estimate of residual error variance (across all subgroups from the analysis of covariance) divided by the subgroup sample size.
Gastroenterology  , e7DOI: ( /j.gastro )
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6. Figure 3
Pharmacogenetics of CNR1 rs and colonic motility index. Treatment effects were most prominently suggested in IBS-D/A and the CNR1 rs genotype CC for proximal left colon MI (P = .075). Data reported are least squares (LS) means and standard errors (SEM). The error bars are based on the square root of the ratio: pooled estimate of residual error variance (across all subgroups from the analysis of covariance) divided by the subgroup sample size.
Gastroenterology  , e7DOI: ( /j.gastro )
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7. Figure 4
Pharmacogenetics of FAAH and colonic motility index. Differential treatment effects among FAAH rs genotypes (CC vs CA/AA) and IBS subtypes were observed for proximal left colon MI (P = .09) and were most pronounced in IBS-D/A and CA/AA (P = .013). Differential treatment effects were also observed for distal left colon MI (P = .046) and were most pronounced in IBS-C and CC (P = .045). Data reported are least squares (LS) means and standard errors (SEM). The error bars are based on the square root of the ratio: pooled estimate of residual error variance (across all subgroups from the analysis of covariance) divided by the subgroup sample size.
Gastroenterology  , e7DOI: ( /j.gastro )
Copyright © 2011 AGA Institute Terms and Conditions