1. Metabolism of nucleotides
Richard Vytášek 2011

2. Introduction Structure of nucleobases, nucleosides and nucleotides
Metabolic functions effected by nucleotides
Dietetary uptake of nucleotides and their utilization

3. Biosynthesis of nucleotides
Biosynthesis of purine nucleotides de novo (PRPP -> IMP -> AMP, GMP) and its regulation
Purine salvage pathway (Lesch-Nyhan Syndrom)
Biosynthesis of pyrimidine nucleotides de novo and its regulation
Pyrimidine salvage pathway
Biosynthesis of deoxyribonucleotides
Biosynthesis of thymine nucleotides

4. Catabolism of nucleotides and nucleobases
Degradation of nucleotides
Degradation of purine nucleotides
Gout
Degradation of pyrimidine nucleotides
Degradation of thymine

5. Nucleoside analogues
antiviral agents (typically inhibitors of reverse transcriptase – e.g. azidothymidine )
cytostatics (chemotherapy – e.g. cytosine arabinoside )
Ara-C is rapidly converted into cytosine arabinoside triphosphate which damages DNA when the cell cycle holds in the S phase(synthesis of DNA).

6. Literature
Harper´s Illustrated Biochemistry (2006) pp