1. Dynamic Pluripotent Stem Cell States and Their Applications
Jun Wu, Juan Carlos Izpisua Belmonte 
Cell Stem Cell 
Volume 17, Issue 5, Pages (November 2015)
DOI: /j.stem
Copyright © 2015 Elsevier Inc. Terms and Conditions

2. Figure 1 Spatiotemporally Distinct PSC States
PSCs showing different timing and spatial properties have been isolated from the early mouse embryos. Top: illustrations of mouse embryos at different stages of early development. Embryonic cells with totipotent or pluripotent potentials are indicated. Bottom: in vitro cultured cells showing functional features resembling in vivo embryonic cells and categorized into different pluripotent states accordingly. Cell morphologies of mESCs, EpiSCs, and rsEpiSCs are shown.
Cell Stem Cell  , DOI: ( /j.stem )
Copyright © 2015 Elsevier Inc. Terms and Conditions

3. Figure 2 Interspecies Chimeric Complementation
By genetically altering the host embryos (e.g., Pdx1−/−), developmental programs specific for certain lineages and organs can be disabled. Totipotent, pluripotent, or multi-potent stem cells from one species can potentially be used to rescue the organ defects of the host species at different time points during development. And as a result, organs enriched with cells derived from donor stem cells are generated in a xeno environment.
Cell Stem Cell  , DOI: ( /j.stem )
Copyright © 2015 Elsevier Inc. Terms and Conditions