Presentation is loading. Please wait.

Presentation is loading. Please wait.

Loss of CRNN expression is associated with advanced tumor stage and poor survival in patients with esophageal squamous cell carcinoma  Po-Kuei Hsu, MD,

Published byLynne York Modified over 5 years ago

Similar presentations

Presentation on theme: "Loss of CRNN expression is associated with advanced tumor stage and poor survival in patients with esophageal squamous cell carcinoma  Po-Kuei Hsu, MD,"— Presentation transcript:

1 Loss of CRNN expression is associated with advanced tumor stage and poor survival in patients with esophageal squamous cell carcinoma  Po-Kuei Hsu, MD, Hua-Ling Kao, MD, Hsuan-Yu Chen, PhD, Chueh-Chuan Yen, MD, PhD, Yu-Chung Wu, MD, Wen-Hu Hsu, MD, Teh- Ying Chou, MD, PhD  The Journal of Thoracic and Cardiovascular Surgery  Volume 147, Issue 5, Pages e4 (May 2014) DOI: /j.jtcvs Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 Representative images of immunohistochemical stains in esophageal squamous cell carcinoma sections: A, no staining at all, defined as negative CRNN staining; B, little staining, defined as negative CRNN staining; and C, positive CRNN staining. The Journal of Thoracic and Cardiovascular Surgery  , e4DOI: ( /j.jtcvs ) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Patients with positive CRNN protein expression (red line) had significantly better overall survival than those with negative CRNN expression (blue line). The Journal of Thoracic and Cardiovascular Surgery  , e4DOI: ( /j.jtcvs ) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

4 Figure E1 Tissue microarray sections.
The Journal of Thoracic and Cardiovascular Surgery  , e4DOI: ( /j.jtcvs ) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

5 Figure E2 Left, Positive and, right, negative controls. Normal esophageal mucosal cells served as a positive control, because they are known to exhibit strong CRNN expression. The same procedure was followed, except that the primary antibody was replaced with phosphate-buffered saline. The Journal of Thoracic and Cardiovascular Surgery  , e4DOI: ( /j.jtcvs ) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

6 Figure E3 CRNN expression in 16 patients with esophageal squamous cell carcinoma patient cohort. The CRNN expression in the tumor tissue was significantly lower than that in the normal mucosa (P = 4 × 10−7). The Journal of Thoracic and Cardiovascular Surgery  , e4DOI: ( /j.jtcvs ) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

7 Figure E4 Survival analyses stratified according to A and B, T stage, C and D, N stage, and E and F, pathologic stage also showed a trend toward better survival in patients with positive CRNN (green lines) expression compared with those with negative CRNN expression (blue lines), although the trend was not significant. The Journal of Thoracic and Cardiovascular Surgery  , e4DOI: ( /j.jtcvs ) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Download ppt "Loss of CRNN expression is associated with advanced tumor stage and poor survival in patients with esophageal squamous cell carcinoma  Po-Kuei Hsu, MD,"

Similar presentations

The prognostic importance of the number of involved lymph nodes in esophageal cancer: Implications for revisions of the American Joint Committee on Cancer.

The prognostic importance of the number of involved lymph nodes in esophageal cancer: Implications for revisions of the American Joint Committee on Cancer.
Vascular endothelial growth factor expression in non-small-cell lung cancer: Prognostic significance in squamous cell carcinoma  Hideyuki Imoto, MD, Toshihiro.

Vascular endothelial growth factor expression in non-small-cell lung cancer: Prognostic significance in squamous cell carcinoma  Hideyuki Imoto, MD, Toshihiro.
Manuel J. Antunes, MD, PhD, DSc 

Manuel J. Antunes, MD, PhD, DSc 
Stephen R. Broderick, MD, MPHS 

Stephen R. Broderick, MD, MPHS 
Phosphorylated mammalian target of rapamycin expression is associated with the response to chemoradiotherapy in patients with esophageal squamous cell.

Phosphorylated mammalian target of rapamycin expression is associated with the response to chemoradiotherapy in patients with esophageal squamous cell.
Ugonna N. Ihekweazu, BS, William D. Travis, MD, Raja M. Flores, MD 

Ugonna N. Ihekweazu, BS, William D. Travis, MD, Raja M. Flores, MD 
Do tumor location and grade affect survival in pT2N0M0 esophageal squamous cell carcinoma?  Dongrong Situ, MD, Junye Wang, MD, PhD, Peng Lin, MD, PhD,

Do tumor location and grade affect survival in pT2N0M0 esophageal squamous cell carcinoma?  Dongrong Situ, MD, Junye Wang, MD, PhD, Peng Lin, MD, PhD,
Mitral stenosis with pulmonary hypertension: We should operate early

Mitral stenosis with pulmonary hypertension: We should operate early
Characterization of microRNA transcriptome in tumor, adjacent, and normal tissues of lung squamous cell carcinoma  Jun Wang, MD, PhD, Zhi Li, MD, PhD,

Characterization of microRNA transcriptome in tumor, adjacent, and normal tissues of lung squamous cell carcinoma  Jun Wang, MD, PhD, Zhi Li, MD, PhD,
Effect of tumor size on prognosis in patients with non–small cell lung cancer: The role of segmentectomy as a type of lesser resection  Morihito Okada,

Effect of tumor size on prognosis in patients with non–small cell lung cancer: The role of segmentectomy as a type of lesser resection  Morihito Okada,
Prognostic Significance of TAZ Expression in Resected Non-Small Cell Lung Cancer  Mian Xie, MD, PhD, Li Zhang, MD, Chao-Sheng He, MD, Jin-Hui Hou, MD,

Prognostic Significance of TAZ Expression in Resected Non-Small Cell Lung Cancer  Mian Xie, MD, PhD, Li Zhang, MD, Chao-Sheng He, MD, Jin-Hui Hou, MD,
Prognostic significance of histologic differentiation, carcinoembryonic antigen value, and lymphovascular invasion in stage I non–small cell lung cancer 

Prognostic significance of histologic differentiation, carcinoembryonic antigen value, and lymphovascular invasion in stage I non–small cell lung cancer 
Impact of tumor size on outcomes after anatomic lung resection for stage 1A non–small cell lung cancer based on the current staging system  Shamus R.

Impact of tumor size on outcomes after anatomic lung resection for stage 1A non–small cell lung cancer based on the current staging system  Shamus R.
Yih-Leong Chang, MD, Chen-Tu Wu, MD, Yung-Chie Lee, MD, PhD 

Yih-Leong Chang, MD, Chen-Tu Wu, MD, Yung-Chie Lee, MD, PhD 
The role of mitochondrial DNA alterations in esophageal squamous cell carcinomas  Chen-Sung Lin, MD, Shi-Chuan Chang, MD, PhD, Liang-Shun Wang, MD, Teh-Ying.

The role of mitochondrial DNA alterations in esophageal squamous cell carcinomas  Chen-Sung Lin, MD, Shi-Chuan Chang, MD, PhD, Liang-Shun Wang, MD, Teh-Ying.
Co-Overexpression of Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1 Adversely Affects the Postoperative Survival in Non-small Cell Lung Cancer 

Co-Overexpression of Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1 Adversely Affects the Postoperative Survival in Non-small Cell Lung Cancer 
A novel biomarker for the detection of esophageal adenocarcinoma

A novel biomarker for the detection of esophageal adenocarcinoma
Clinical and biological significance of stem-like CD133+CXCR4+ cells in esophageal squamous cell carcinoma  Chunlai Lu, MD, Fengkai Xu, MD, Jie Gu, MD,

Clinical and biological significance of stem-like CD133+CXCR4+ cells in esophageal squamous cell carcinoma  Chunlai Lu, MD, Fengkai Xu, MD, Jie Gu, MD,
Outcomes of unexpected pathologic N1 and N2 disease after video-assisted thoracic surgery lobectomy for clinical stage I non–small cell lung cancer  Hong.

Outcomes of unexpected pathologic N1 and N2 disease after video-assisted thoracic surgery lobectomy for clinical stage I non–small cell lung cancer  Hong.
High Expression of Zinc-Binding Protein-89 Predicts Decreased Survival in Esophageal Squamous Cell Cancer  Shu-Mei Yan, MD, Hui-Ni Wu, MB, Fan He, MD,

High Expression of Zinc-Binding Protein-89 Predicts Decreased Survival in Esophageal Squamous Cell Cancer  Shu-Mei Yan, MD, Hui-Ni Wu, MB, Fan He, MD,

Similar presentations

Ads by Google