1. Rapid increase in non-vaccine serotypes causing invasive pneumococcal disease in England and Wales, 2000–17: a prospective national observational cohort study 
Shamez N Ladhani, MRCPCH, Sarah Collins, MPH, Abdelmajid Djennad, PhD, Carmen L Sheppard, PhD, Prof Ray Borrow, PhD, Norman K Fry, PhD, Prof Nicholas J Andrews, PhD, Prof Elizabeth Miller, FRCPath, Mary E Ramsay, FFPHM 
The Lancet Infectious Diseases 
Volume 18, Issue 4, Pages (April 2018)
DOI: /S (18)
Copyright © 2018 Elsevier Ltd Terms and Conditions

2. Figure 1
Corrected trends in IPD incidence in England and Wales for all ages and by age group
The epidemiological year runs from July to June. The vertical lines labelled PCV7 and PCV13 denote introduction of the seven-valent and 13-valent pneumococcal conjugate vaccines (PCVs) into the national childhood immunisation programme. PCV7=invasive pneumococcal disease (IPD) due to the serotypes included in the seven-valent PCV. PCV13 only=IPD due to the additional six serotypes included in the 13-valent PCV. Non-PCV13=serotypes responsible for IPD that are not included in the 13-valent PCV.
The Lancet Infectious Diseases  , DOI: ( /S (18) )
Copyright © 2018 Elsevier Ltd Terms and Conditions

3. Figure 2
Corrected overall and age group-specific trends in invasive pneumococcal disease incidence due to the additional PCV13 serotypes and PCV13-related serotype 6C 7 years after the introduction of PCV13 in England and Wales
The epidemiological year runs from July to June. The vertical lines labelled PCV7 and PCV13 denote the introduction of the seven-valent and 13-valent pneumococcal conjugate vaccines into the national childhood immunisation programme.
The Lancet Infectious Diseases  , DOI: ( /S (18) )
Copyright © 2018 Elsevier Ltd Terms and Conditions

4. Figure 3
Corrected overall and age group-specific trends in invasive pneumococcal disease incidence due to the main replacing serotypes 7 years after the introduction of PCV13 in England and Wales
The epidemiological year runs from July to June. The vertical lines labelled PCV7 and PCV13 denote the introduction of the seven-valent and 13-valent pneumococcal conjugate vaccines into the national childhood immunisation programme.
The Lancet Infectious Diseases  , DOI: ( /S (18) )
Copyright © 2018 Elsevier Ltd Terms and Conditions