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Macrophage Activation: On PAR with LPS

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1 Macrophage Activation: On PAR with LPS
Florian J. Bock, Paul Chang  Chemistry & Biology  Volume 22, Issue 4, Pages (April 2015) DOI: /j.chembiol Copyright © 2015 Elsevier Ltd Terms and Conditions

2 Figure 1 PARP1 Enzymatic Activity Is Highly Upregulated in Cells Undergoing Necrosis Upon lysis of the necrotic cell, the PAR synthesized by PARP1 is released into the extracellular space. Extracellular PAR can then be detected by TLR2 and TLR4, which are endocytosed and signal the activation of NFκB, resulting in the secretion of cytokines and activation of an inflammatory response. Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2015 Elsevier Ltd Terms and Conditions

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