1. Wait, Wait … OK Now Go In: iNKT Cells Resolve Liver Inflammation
Haiguang Wang, Kristin A. Hogquist 
Immunity 
Volume 47, Issue 4, Pages (October 2017)
DOI: /j.immuni
Copyright © 2017 Elsevier Inc. Terms and Conditions

2. Figure 1
iNKT Cells Promote Resolution of Inflammation and Tissue Repair in the Liver
Upon induction of sterile liver injury, a large number of neutrophils and CCR2hiCX3CR1lo monocytes are recruited to the injury foci at early time points (≤4 hr). Starting at 4–8 hr, iNKT cells accumulate at the boundary of the injury site and become arrested as a result of TCR stimulation and activation by the cytokines IL-12 and IL-18 from an unidentified source (shown as a question mark). Kupffer cells (KCs), liver sinusoid endothelial cells (LSECs), and other unidentified antigen-presenting cells (APCs) (shown as a question mark) present neo-lipid antigens to iNKT cells at this point. Eventually (after 48 hr), the iNKT cells infiltrate the injury foci. Activated iNKT cells produce IL-4, leading to enhanced proliferation of hepatocytes surrounding the injury site, the switch of monocyte subtypes from CCR2hiCX3CR1lo to CCR2loCX3CR1hi, and reduced collagen deposition, all of which are critical for optimal tissue repair.
Immunity  , DOI: ( /j.immuni )
Copyright © 2017 Elsevier Inc. Terms and Conditions