1. The Dark Age(ing) of the Inflammasome
Konrad Aden, Philip Rosenstiel 
Immunity 
Volume 46, Issue 2, Pages (February 2017)
DOI: /j.immuni
Copyright © 2017 Elsevier Inc. Terms and Conditions

2. Figure 1
A Vicious Circle of Inflammasome Activation Is Triggered by Nucleotide Metabolites and Can Be Intercepted by Dietary Caffeine
Chronic overactivation of the inflammasome leads to subclinical IL-1β-associated inflammation, which is associated with arterial hypertension and kidney inflammation in the elderly. On a cellular level, low-grade inflammation leads to platelet activation and endothelial damage, which in turn provokes the accumulation of nucleotide secondary metabolites (adenin or N4A). Adenin and N4A are in turn able to stimulate inflammasome activity and thereby induce the vicious circle of inflammageing. Dietary caffeine exerts inhibitory effects on the inflammasome by a so-far unrecognized mechanism. Putative mechanisms include caffeine induced increase of intracellular cAMP, induction of autophagy, or blockade of the adenosin receptor.
Immunity  , DOI: ( /j.immuni )
Copyright © 2017 Elsevier Inc. Terms and Conditions