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Component-resolved diagnosis of kiwifruit allergy with purified natural and recombinant kiwifruit allergens  Merima Bublin, PhD, Marina Pfister, MD, Christian.

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Presentation on theme: "Component-resolved diagnosis of kiwifruit allergy with purified natural and recombinant kiwifruit allergens  Merima Bublin, PhD, Marina Pfister, MD, Christian."— Presentation transcript:

1 Component-resolved diagnosis of kiwifruit allergy with purified natural and recombinant kiwifruit allergens  Merima Bublin, PhD, Marina Pfister, MD, Christian Radauer, PhD, Christina Oberhuber, PhD, Sean Bulley, PhD, Åsa Marknell DeWitt, PhD, Jonas Lidholm, PhD, Gerald Reese, PhD, Stefan Vieths, PhD, Heimo Breiteneder, PhD, Karin Hoffmann-Sommergruber, PhD, Barbara K. Ballmer-Weber, MD  Journal of Allergy and Clinical Immunology  Volume 125, Issue 3, Pages e1 (March 2010) DOI: /j.jaci Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 IgE reactivity profiles to kiwifruit extracts and individual allergens in kiwifruit-monosensitized subjects (A1), subjects with kiwifruit and pollen allergy (A2), subjects with kiwifruit, pollen, and latex allergy (A3), and controls with a birch pollen allergy (B), with a pollen and latex allergy (C), and nonatopics (D). Specific IgE concentrations are expressed as CAP classes as described in the Methods section. Extracta, Commercial extract; Extractb, self-produced extract. Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Sensitization profiles to kiwifruit allergen components in kiwifruit-monosensitized subjects (A1), subjects with kiwifruit and pollen allergy (A2), and subjects with kiwifruit, pollen, and latex allergy (A3). Dotted lines indicate the 0.35 kUA/L cutoff level. Median values are indicated. Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Specific serum IgE levels to the individual allergens of patients responding with more severe or systemic symptoms (see Table I, symptoms by case history) to ingestion of kiwifruit were compared with those with a pure OAS. Dotted lines indicate the 0.35 kUA/L cutoff level. Median values are indicated. Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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