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Evaluation of the relationship between plasma concentrations of en- and zuclomiphene and induction of ovulation in anovulatory women being treated with.

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Presentation on theme: "Evaluation of the relationship between plasma concentrations of en- and zuclomiphene and induction of ovulation in anovulatory women being treated with."— Presentation transcript:

1 Evaluation of the relationship between plasma concentrations of en- and zuclomiphene and induction of ovulation in anovulatory women being treated with clomiphene citrate  Cyrus Ghobadi, M.B.Ch.B., Saad Amer, M.D., Hany Lashen, M.D., Martin S. Lennard, Ph.D., William L. Ledger, D.Phil., Amin Rostami- Hodjegan, Ph.D.  Fertility and Sterility  Volume 91, Issue 4, Pages (April 2009) DOI: /j.fertnstert Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Response to CC at different doses. R50 = responders to 50 mg; NR50 = nonresponders to 50 mg; R100 = responders to 100 mg; NR100 = nonresponders to 100 mg; R150 = responders to 150 mg; NR150 = nonresponders to 150 mg. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Plasma concentrations of En (top) and Zu (middle) and their ratio (bottom) during the three cycles of treatment with CC. Values are expressed as mean ± SE; the vertical broken line on day 21 (D21) indicates the end of the cycle when patients were assessed for ovulation. A = responders and nonresponders to 50 mg; B = responders and nonresponders to 100 mg; C = responders and nonresponders to 150 mg. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

4 Figure 3 The natural logarithm (LN) (mean ± SE) of the Zu/En ratio in plasma, in the first cycle of treatment. Patients are grouped retrospectively according to the final outcome of their therapy. aP<.05. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions


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