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Jennifer L. Nichols, D. O. , Eric J. Bieber, M. D. , Jennifer S

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Presentation on theme: "Jennifer L. Nichols, D. O. , Eric J. Bieber, M. D. , Jennifer S"— Presentation transcript:

1 Case of sisters with complete androgen insensitivity syndrome and discordant Müllerian remnants 
Jennifer L. Nichols, D.O., Eric J. Bieber, M.D., Jennifer S. Gell, M.D.  Fertility and Sterility  Volume 91, Issue 3, Pages 932.e e18 (March 2009) DOI: /j.fertnstert Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Sister 1. (A) Left elongated gonad visualized at laparoscopy. Adjacent to the gonad is a tubal structure with distal fimbria and a paratubal cyst. (B) Histopathology of testicular tissue showing immature testicles containing immature germ cells and spermatagonia with decreased tubular diameter. Scattered groups of Leydig cells appearing immature. (C) Histopathology of hypoplastic uterine tissue removed demonstrating fragments of smooth muscle. (Pathology photographs: Xiaohong Mary Zhang, M.D., Staff Physician, Pathology, Department of Laboratory Medicine & Pathology, Geisinger Health System.) Fertility and Sterility  , 932.e e18DOI: ( /j.fertnstert ) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Sister 2. (A) Right gonad visualized at laparoscopy showing no Müllerian structures. (B) Histopathology revealed testicular tissue with benign Sertoli cell adenomas, entirely in the testicular parenchyma, consisting of relatively bland well-formed tubules lined by benign columnar cells. No evidence of spermatogenesis is seen in any of the structures. No malignant degeneration. (Pathology photographs: Xiaohong Mary Zhang, M.D., Staff Physician, Pathology, Department of Laboratory Medicine & Pathology, Geisinger Health System.) Fertility and Sterility  , 932.e e18DOI: ( /j.fertnstert ) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions


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