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Disease activities evaluated as a comparison between abatacept plus MTX and placebo plus MTX groups. Disease activities evaluated as a comparison between.

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Presentation on theme: "Disease activities evaluated as a comparison between abatacept plus MTX and placebo plus MTX groups. Disease activities evaluated as a comparison between."— Presentation transcript:

1 Disease activities evaluated as a comparison between abatacept plus MTX and placebo plus MTX groups.
Disease activities evaluated as a comparison between abatacept plus MTX and placebo plus MTX groups. (A) ACR20 response rate (co-primary endpoint) assessed at week 16. P value was based on the continuity corrected χ2 test. (B) ACR20, 50 and 70 response rates over time up to 52 weeks. The patients who received rescue abatacept treatment, or who withdrew for any reason, were considered as non-responders from that time point forward. Dotted lines indicate time points at week 16 (secondary endpoints for ACR50 and 70 response rates), week 24 and week 52 (tertiary endpoints for ACR20, 50 and 70). The shapes indicate ACR20 (circles), ACR50 (triangles) and ACR70 (squares) response rates in the abatacept plus MTX (filled) and placebo plus MTX (open) groups. (C) Adjusted mean change from baseline in DAS28 (CRP) over time up to 52 weeks. Dotted lines indicate time points at week 16 (secondary endpoint), week 24 and week 52 (tertiary endpoints). Data after the initiation of rescue abatacept treatment were excluded. Error bars indicate the SE. (D–F) Remission rates with DAS28 (CRP) (D), SDAI (E) and CDAI (F) over time up to 52 weeks. Dotted lines indicate time points at week 16, week 24 and week 52 (tertiary endpoints). The circles show remission rates for the abatacept plus MTX (filled) and placebo plus MTX (open) groups. The remission was defined in this study as DAS28 (CRP) <2.6, SDAI ≤3.3 and CDAI ≤2.8. Patients with missing data due to early discontinuation or response after the initiation of rescue abatacept treatment were treated as non-responders. (G) Proportion of patients with HAQ-DI response over time up to 52 weeks. Dotted lines indicate time points at week 16, week 24 and week 52 (tertiary endpoints). The circles show response rates for the abatacept plus MTX (filled) and placebo plus MTX (open) groups. The HAQ-DI response was defined as a score reduction of ≥0.3 from baseline. ABA, abatacept; ACR20/50/70, American College of Rheumatology 20/50/70; CDAI, Clinical Disease Activity Index; CRP, C-reactive protein; DAS28, Disease Activity Score 28; HAQ-DI, Health Assessment Questionnaire-Disability Index; MTX, methotrexate; PBO, placebo; SDAI, Simplified Disease Activity Index. Tsukasa Matsubara et al. RMD Open 2018;4:e000813 Copyright © BMJ Publishing Group & EULAR. All rights reserved.

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