1. Ioannis Smyrnias et al. JACC 2019;73:1795-1806
Induction of UPRmt Markers Under Various Stress Conditions in Cardiomyocytes and in an In Vivo Model of Chronic Pressure Overload (A and B) Response of cardiomyocytes to paraquat (100 or 500 μmol/l for 6, 24, and 48 h). (C and D) Response of cardiomyocytes to isoproterenol (1 or 100 μmol/l for 6, 24, and 48 h). (E) Response of cardiomyocytes to G-TPP (10 μmol/l for 4 and 8 h). *p < 0.05 versus respective control for changes in mRNA levels. #p < 0.05 versus 6-h treatment. ˆp < 0.05 versus 24-h treatment. (F) Effect of chronic pressure overload (TAC) on UPRmt markers. *p < 0.05 versus sham-operated control mice or control conditions in NRVM. Dashed line denotes mRNA levels under control conditions. Data are mean ± SEM, n = 4 to 8/group. Atf5 = cyclic AMP-dependent transcription factor ATF-5; CHOP = CCAT-enhancer-binding protein homologous protein; ClpP = ATP-dependent Clp protease proteolytic subunit; G-TPP = gamitrinib-triphenylphosphonium; Hsp10 = Heat shock 10kDa protein 1; Hsp60 = Heat shock 60kDa protein 1; LonP1 = Lon protease homolog, mitochondrial; mtDNAj = mitochondrial pre-sequence translocase-associated motor complex protein; UPRmt = mitochondrial unfolded protein response.
Ioannis Smyrnias et al. JACC 2019;73:
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