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Inverse Relationship between Vitiligo-Related Genes and Skin Cancer Risk
Wenting Wu, Christopher I. Amos, Jeffrey E. Lee, Qingyi Wei, Kavita Y. Sarin, Jiali Han Journal of Investigative Dermatology Volume 138, Issue 9, Pages (September 2018) DOI: /j.jid Copyright © 2018 The Authors Terms and Conditions
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Figure 1 Effect sizes estimated in skin cancer versus vitiligo, for the 58 SNPs from a previously reported vitiligo GWAS (Jin et al., 2016). Both x- and y-axes display odds ratio values associated with the minor allele. SNPs with P < 8.6 × 10-4 (significant after Bonferroni correction) are labeled with the gene name corresponding to that locus. Effect size estimated in vitiligo was reported by a previous GWAS study (Jin et al., 2016). (a) Effect sizes estimated in melanoma versus vitiligo. SNPs with P < 0.5 in the meta-analysis are shown in red; the other SNPs are shown in blue. For effect sizes estimated in the melanoma meta-analysis, SNPs with heterogeneity statistics I2 ≥ 60% were calculated with a random-effects method. (b) Effect sizes estimated in basal cell carcinoma versus vitiligo. SNPs with P < 0.05 are shown in red; other SNPs are shown in blue. (c) Effect sizes estimated in squamous cell carcinoma versus vitiligo. SNPs with P < 0.05 are shown in red; other SNPs are shown in blue. GWAS, genome-wide association study; SNP, single-nucleotide polymorphism. Journal of Investigative Dermatology , DOI: ( /j.jid ) Copyright © 2018 The Authors Terms and Conditions
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