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Hippocampal Dentate Mossy Cells Improve Their CV and Trk into the Limelight
Aaron D. Milstein, Ivan Soltesz Neuron Volume 95, Issue 4, Pages (August 2017) DOI: /j.neuron Copyright © 2017 Elsevier Inc. Terms and Conditions
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Figure 1 Long-Term Plasticity Is Selectively Present at Synapses from Mossy Cells to Granule Cells, but Not from Mossy Cells to GABAergic Interneurons (A) Simplified neuronal circuit of the dentate gyrus. MC, mossy cell; INT, GABAergic interneuron; GC, granule cell; MECII and LECII, layer II of the medial and lateral entorhinal cortex, respectively. (B) Changes in schematized postsynaptic EPSPs in granule cells following an LTP-inducing stimulus (burst firing of mossy cells); the EPSPs are illustrated as appearing in closely timed pairs after being evoked by paired-pulse activation of mossy cell axons in the inner molecular layer. (C) Summary of alterations in various synaptic parameters after mossy-cell-evoked LTP in granule cells; note that mossy cell to interneuron synapses failed to show LTP, resulting in unchanged disynaptic IPSCs in granule cells following mossy cell activation. Neuron , DOI: ( /j.neuron ) Copyright © 2017 Elsevier Inc. Terms and Conditions
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