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Induction and Excretion of Ultraviolet-Induced 8-Oxo-2′-deoxyguanosine and Thymine Dimers In Vivo: Implications for PUVA  Marcus S. Cooke, Mark D. Evans,

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Presentation on theme: "Induction and Excretion of Ultraviolet-Induced 8-Oxo-2′-deoxyguanosine and Thymine Dimers In Vivo: Implications for PUVA  Marcus S. Cooke, Mark D. Evans,"— Presentation transcript:

1 Induction and Excretion of Ultraviolet-Induced 8-Oxo-2′-deoxyguanosine and Thymine Dimers In Vivo: Implications for PUVA  Marcus S. Cooke, Mark D. Evans, Kayuri Patel, Angela Barnard, Joseph Lunec  Journal of Investigative Dermatology  Volume 116, Issue 2, Pages (February 2001) DOI: /j x Copyright © 2001 The Society for Investigative Dermatology, Inc Terms and Conditions

2 Figure 1 Spectral characteristic of UVA-emitting fluorescent tubes. Irradiant intensity is plotted against wavelength. Journal of Investigative Dermatology  , DOI: ( /j x) Copyright © 2001 The Society for Investigative Dermatology, Inc Terms and Conditions

3 Figure 2 Competitive ELISA analysis of urinary 8-oxodG. Healthy, human volunteers (n = 7) were exposed to a single suberythemal dose of UV. Daily first void urine samples were collected prior to exposure (day 0) and subsequently over a period of 13 d. Urine samples were also collected from an age- and sex-matched, unexposed control group (n = 7) over the same period of study. Values are corrected to represent percentage change from pre-exposure levels (day 0). Bars represent mean ± standard deviations. Asterisks indicate a significant (*p = 0.05) difference from pre-exposure values (day 0), determined by Fisher's least significant difference test, and a significant (***p < ) difference between UV-exposed and unexposed volunteers, determined by t test. Both are the results of secondary statistical analysis. Journal of Investigative Dermatology  , DOI: ( /j x) Copyright © 2001 The Society for Investigative Dermatology, Inc Terms and Conditions

4 Figure 3 Competitive ELISA analysis of urinary T<>T. Healthy, human volunteers (n = 7) were exposed to a single suberythemal dose of UV. Daily first void urine samples were collected prior to exposure (day 0) and subsequently over a period of 13 d. Urine samples were also collected from an age- and sex-matched, unexposed control group (n = 7) over the same period of study. Values are corrected to represent percentage change from pre-exposure levels (day 0). Bars represent mean ± standard deviations. Asterisks indicate a significant (*p = 0.05) difference from pre-exposure values (day 0), determined by Fisher's least significant difference test, and a significant (**p < 0.001; ***p < ) difference between UV-exposed and unexposed volunteers, determined by t test. Both are the results of secondary statistical analysis. Journal of Investigative Dermatology  , DOI: ( /j x) Copyright © 2001 The Society for Investigative Dermatology, Inc Terms and Conditions


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