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Volume 139, Issue 2, Pages (August 2010)

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1 Volume 139, Issue 2, Pages 491-498 (August 2010)
Nucleos(t)ide Analogues Only Induce Temporary Hepatitis B e Antigen Seroconversion in Most Patients With Chronic Hepatitis B  Jurriën G.P. Reijnders, Moniek J. Perquin, Ningping Zhang, Bettina E. Hansen, Harry L.A. Janssen  Gastroenterology  Volume 139, Issue 2, Pages (August 2010) DOI: /j.gastro Copyright © 2010 AGA Institute Terms and Conditions

2 Figure 1 Kaplan–Meier curve for the cumulative probabilities of achieving HBeAg seroconversion during nucleos(t)ide analogue therapy. (A) Number of patients who have not achieved HBeAg seroconversion and are still in follow-up evaluation. (B) Number of patients who are still in follow-up evaluation, whether or not they have achieved HBeAg seroconversion. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2010 AGA Institute Terms and Conditions

3 Figure 2 Kaplan–Meier curve for the cumulative probabilities of developing serologic recurrence, defined as reappearance of HBeAg confirmed by HBeAg positivity in a consecutive sample, after HBeAg seroconversion. (A) Number of patients who have not developed serologic recurrence and are still in follow-up evaluation. (B) Number of patients who are still in follow-up evaluation, whether or not they have developed serologic recurrence. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2010 AGA Institute Terms and Conditions

4 Figure 3 Kaplan–Meier curve for the cumulative probabilities of developing virologic recurrence, defined as an increase of HBV DNA to greater than 10,000 copies/mL after HBeAg seroconversion and previously having been less than 10,000 copies/mL, confirmed in a consecutive sample. (A) Number of patients who have not developed virologic recurrence and are still in follow-up evaluation. (B) Number of patients who are still in follow-up evaluation, whether or not they have developed virologic recurrence. Eight patients had ongoing viral replication with HBV-DNA levels greater than 10,000 copies/mL despite the achievement of HBeAg seroconversion and were excluded from this analysis. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2010 AGA Institute Terms and Conditions

5 Figure 4 Proportion of patients who developed serologic and/or virologic recurrence after nucleos(t)ide analogue-induced HBeAg seroconversion, and causes of serologic and/or virologic recurrence, specified per treatment regimen. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2010 AGA Institute Terms and Conditions


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