1. Switch to RAL-containing regimen
ARV-trial.com
Switch to RAL-containing regimen
Canadian Study
CHEER
Montreal Study
EASIER
SWITCHMRK
SPIRAL
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2. Montreal Study: Switch ENF to RAL
Pilot, open-label retrospective study
28 adults on salvage therapy with enfuvirtide-based regimen and HIV-1 RNA < 50 c/mL
Switch of enfuvirtide to RAL 400 mg bid, the remainder of the salvage regimen being unchanged. At the time of the switch:
ENF had been administered for a median of 25 months
Salvage regimen: 1 PI/r, N = 27, 1 NNRTI, N = 6
Follow-up of 6 months available for 27/28 patients
26 maintained HIV-1 RNA < 50 c/mL
1 single blip at 56 c/mL at W24
No significant changes in the CD4 counts
ENF-related injection site reactions resolved in all patients
RAL was well tolerated
Montreal
Talbot A, JAIDS 2009;51:362-4