1. Magnesium transport in hypertension
Bruno Sontia, Rhian M. Touyz 
Pathophysiology 
Volume 14, Issue 3, Pages (December 2007)
DOI: /j.pathophys
Copyright © 2007 Elsevier Ireland Ltd Terms and Conditions

2. Fig. 1
Magnesium transport mechanisms that may be altered in vascular smooth muscle cells in hypertension. Decreased Mg2+ influx, due to reduced TRPM7 expression/activity and decreased Mg2+ diffusion across cell membranes, may lead to reduced concentrations of intracellular free Mg2+ ([Mg2+]i). Vasoactive agents, including Ang II, aldosterone and bradykinin, and mechanical factors, such as shear stress, stretch and pressure, modulate vascular TRPM7 activity. Increased Mg2+ efflux, due to increased activation of Na+-dependent and Na+-independent exchangers may also contribute to intracellular Mg2+ deficiency in hypertension: (+) increased activity; (−) decreased activity.
Pathophysiology  , DOI: ( /j.pathophys )
Copyright © 2007 Elsevier Ireland Ltd Terms and Conditions