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Statins and other agents for vascular inflammation

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Presentation on theme: "Statins and other agents for vascular inflammation"— Presentation transcript:

1 Statins and other agents for vascular inflammation
Christopher D. Owens, MD, MSc  Journal of Vascular Surgery  Volume 56, Issue 6, Pages (December 2012) DOI: /j.jvs Copyright © 2012 Society for Vascular Surgery Terms and Conditions

2 Fig 1 The receiver operating characteristic curves (ROC) and area under the ROC curves are presented for 225 patients undergoing lower extremity bypass surgery. A, A clinical model for prediction of midterm mortality was created with age, diabetes mellitus (DM), extant coronary disease (CAD), and the presence of critical limb ischemia (CLI). Subsequently added to the clinical model were (B) renal function, as defined by estimated glomerular filtration rate (eGFR), (C) eGFR and albumin, and (D) e-GFR, albumin, and high-sensitivity C-reactive protein (hsCRP). Each biochemical parameter improved the accuracy of the model as evidenced by the increasing area under the curve value. The final model, consisting of seven variables, has an 82% accuracy of predicting midterm mortality. Adapted from Owens et al.42 Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2012 Society for Vascular Surgery Terms and Conditions

3 Fig 2 Venn diagram of 225 patients undergoing peripheral bypass surgery and followed up for 2.5 years. There is considerable overlap among subsets of patients with malnutrition, renal impairment, and inflammation and the synergism of different mechanisms for the hazard of death. Of 225 individuals in this study, 74 (33%) had an estimated glomerular filtration (eGFR) <60 mL/min/1.73 m2, 63 (28%) had an albumin <3.5 mg/dL, and 80 (36%) had a high-sensitivity C-reactive protein (hsCRP) >5.0 mg/L. The 21 individuals (9%) located within the intersection of the three circles have a hazard ratio for death of 9.08. Adapted from Owens et al.42 Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2012 Society for Vascular Surgery Terms and Conditions

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