1. MMV688271 is a novel antifungal agent.
MMV is a novel antifungal agent. (A) Growth curve analysis for C. neoformans H99 and C. albicans SC5314 in YNB medium at 30°C in the absence (control) or presence of 1 µM MMV688271, or the vehicle control (DMSO). MMV blocked growth of both fungal pathogens. Results are means ± standard errors of the means of two independent experiments, each performed at least in duplicate. (B) Chemical structure of MMV (C) MMV inhibited fungal growth at 37°C. C. neoformans H99 or C. albicans SC5314 cells were incubated in YNB medium at 37°C in the absence (control) or presence of 1 µM MMV or the vehicle control (DMSO). Results are means + standard deviations (SD) of two independent experiments, each performed in duplicate. *, P < (D) MMV inhibits growth of the fungal pathogen C. gattii. The C. gattii wild-type strain R265 was grown in YNB medium at 30°C in the absence (control) or presence of 1 µM MMV or the vehicle control (DMSO). Results are the means + SD of two independent experiments, each performed in duplicate. *, P <
François L. Mayer, and James W. Kronstad mSphere 2017; doi: /mSphere