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ROR1-Specific Chimeric Antigen Receptor (CAR) NK Cell Immunotherapy for High Risk Neuroblastomas and Sarcomas  Haein Park, Aradhana Awasthi, Janet Ayello,

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Presentation on theme: "ROR1-Specific Chimeric Antigen Receptor (CAR) NK Cell Immunotherapy for High Risk Neuroblastomas and Sarcomas  Haein Park, Aradhana Awasthi, Janet Ayello,"— Presentation transcript:

1 ROR1-Specific Chimeric Antigen Receptor (CAR) NK Cell Immunotherapy for High Risk Neuroblastomas and Sarcomas  Haein Park, Aradhana Awasthi, Janet Ayello, Yaya Chu, Stanley Riddell, Jeremy Rosenblum, Dean A. Lee, Mitchell S. Cairo  Biology of Blood and Marrow Transplantation  Volume 23, Issue 3, Pages S136-S137 (March 2017) DOI: /j.bbmt Copyright © Terms and Conditions

2 Figure 1 NK cells significantly expanded by modified K562-mb.II.21-41BBL (A) and ROR1-CAR expression of ROR1-CAR aNK was significantly increased compared to Mock-aNK (B). Biology of Blood and Marrow Transplantation  , S136-S137DOI: ( /j.bbmt ) Copyright © Terms and Conditions

3 Figure 2 ROR1-CAR-aNK cells had a specific cytotocixity against ROR1 positive Neuroblastoma (A) and Sarcoma cells (B) compared to ROR1 negative expressed cells in vitro (C). Biology of Blood and Marrow Transplantation  , S136-S137DOI: ( /j.bbmt ) Copyright © Terms and Conditions


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