1. Multimode Selective Detection of Mercury by Chiroptical Fluorescent Sensors
Zhaohua Dai
Department of Chemistry and Physical Sciences
Pace University
242nd ACS National Meeting, Denver
08/28/2011

2. Mercury Pollution

3. Minamata Tragedy: Mercury

4. S-containing Fluorescent Hg(II) Sensors
1, Li(I); 2, Na(I); 3, Rb(I); 4, Mg(II); 5, Ca(II); 6, Sr(II); 7, Ba(II); 8, Cr(III); 9, Mn(II); 10, Fe(II); 11, Co(II); 12, Ni(II); 13, Cu(II); 14, Zn(II); 15, Cd(II); 16, Hg(II); 17, Pb(II)
E. M. Nolan, S. J. Lippard
J. AM. CHEM. SOC. 2003, 125,

5. Chiral Fluorescent Probes for Hg2+
Higher Selectivity against Zn2+/Cu2+
Stereochemical Control
2. Better contrast
Fertile Optical Information: Differential Circularly Polarized Fluorescence Excitation (CPE) 5

6. 1st Generation

7. UV Hg-Sensing by MethBQA in CH3CN
Sensor:
10 mM

8. Fluorescence Hg-Sensing by MethBQA in CH3CN

9. CD Hg-Sensing by MethBQA in CH3CN

10. UV Hg-Sensing by MethBQA in 7:3 H2O/CH3CN

11. Fluorescence Hg-Sensing by MethBQA in 7:3 H2O/CH3CN

12. Fluorescence Hg-Sensing by MethBQA in 7:3 H2O/CH3CN

13. CD Hg-Sensing by CysBQA in 7:3 H2O/CH3CN
Kd, Hg= 4.7 ×10-7 M
Kd, Zn= 1.7 ×10-6 M.

14. CD Response of CysBQA to Other Metal Ions

15. Mechanism of Different CD Responses

16. Multimode Selective Detection
Chirality, in press

18. 2nd Generation Sensors
We intend to use these ligands to further develop CPE. 18

20. 3rd Generation

21. Acknowledgements Patrick Carney Amanda Mickley Wenyao Nick Zhang
Nikhil Khosla
Layanne Valdez
Tahshee Washington
Cho Tan
Christine Toledo
Maykel Khilla
Steven Lopez (NYU)
Kirill Grinberg (Midwood High)
Jennifer Lee (NYU)
Michael Isaacman
Prof. James Canary (NYU)
Research Corporation for Science Advancement
Petroleum Research Fund
Pace University (Scholarly Research Fund, Kenan Fund, etc)