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Randomized clinical trial of dexketoprofen/tramadol 25 mg/75 mg in moderate-to-severe pain after total hip arthroplasty  H.J. McQuay, R.A. Moore, A. Berta,

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Presentation on theme: "Randomized clinical trial of dexketoprofen/tramadol 25 mg/75 mg in moderate-to-severe pain after total hip arthroplasty  H.J. McQuay, R.A. Moore, A. Berta,"— Presentation transcript:

1 Randomized clinical trial of dexketoprofen/tramadol 25 mg/75 mg in moderate-to-severe pain after total hip arthroplasty  H.J. McQuay, R.A. Moore, A. Berta, O. Gainutdinovs, B. Fülesdi, N. Porvaneckas, S. Petronis, M. Mitkovic, L. Bucsi, L. Samson, V. Zegunis, M.L. Ankin, M. Bertolotti, B. Pizà-Vallespir, S. Cuadripani, M.P. Contini, A. Nizzardo  British Journal of Anaesthesia  Volume 116, Issue 2, Pages (February 2016) DOI: /bja/aev457 Copyright © 2016 The Author(s) Terms and Conditions

2 Fig 1 Study CONSORT flow diagram. Participant flow, with the numbers of participants who were randomly assigned, received intended treatment, and were analysed for the primary outcome. Analysis populations were as follows: the ITT population included all patients randomized; the safety population included all patients randomized who received at least one dose of study treatment; and the PP population included all ITT patients with no major protocol violations. •, received at least one dose; alloc., allocated; DKP, dexketoprofen trometamol 25 mg; DKP/TRAM, dexketoprofen trometamol/tramadol hydrochloride 25 mg/75 mg; ITT, intention to treat; n, number of patients; PP, per protocol; TRAM, tramadol hydrochloride 100 mg. British Journal of Anaesthesia  , DOI: ( /bja/aev457) Copyright © 2016 The Author(s) Terms and Conditions

3 Fig 2 Observed PI-VAS at rest for the single-dose phase (first 8 h) by treatment (all randomized patients). DKP, dexketoprofen trometamol 25 mg; DKP/TRAM, dexketoprofen trometamol/tramadol hydrochloride 25 mg/75 mg; PI, pain intensity; PI-VAS, pain intensity visual analog scale; TRAM, tramadol hydrochloride 100 mg; VAS, visual analog scale. British Journal of Anaesthesia  , DOI: ( /bja/aev457) Copyright © 2016 The Author(s) Terms and Conditions

4 Fig 3 Observed PI-VAS at rest during the first 48 h of the multiple-dose phase by treatment (all randomized patients). DKP, dexketoprofen trometamol 25 mg; DKP/TRAM, dexketoprofen trometamol/tramadol hydrochloride 25 mg/75 mg; PI, pain intensity; PI-VAS, pain intensity visual analog scale; TRAM, tramadol hydrochloride 100 mg; VAS, visual analog scale. British Journal of Anaesthesia  , DOI: ( /bja/aev457) Copyright © 2016 The Author(s) Terms and Conditions

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