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PolyQ‐huntingtin accelerates EMT. A

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1 PolyQ‐huntingtin accelerates EMT. A
PolyQ‐huntingtin accelerates EMT.A.Immunostaining of sections from MMTV‐PyVT/HdhQ7/Q7 (HdhQ7/Q7) and MMTV‐PyVT/HdhQ111/Q111 (HdhQ111/Q111) tumours (originating from the 3rd mammary gland, 14 weeks) for endogenous E‐cadherin, β‐catenin and α‐SMA.B.Immunoblotting of total extracts from MMTV‐PyVT/HdhQ7/Q7 and MMTV‐PyVT/HdhQ111/Q111 tumours (originating from the 3rd mammary gland, 14 weeks, n = 6 tumours per genotype, two independent immunoblotting) for the presence of ZO‐1, E‐cadherin, β‐catenin, vimentin and α‐tubulin. PolyQ‐huntingtin accelerates EMT.A.Immunostaining of sections from MMTV‐PyVT/HdhQ7/Q7 (HdhQ7/Q7) and MMTV‐PyVT/HdhQ111/Q111 (HdhQ111/Q111) tumours (originating from the 3rd mammary gland, 14 weeks) for endogenous E‐cadherin, β‐catenin and α‐SMA.B.Immunoblotting of total extracts from MMTV‐PyVT/HdhQ7/Q7 and MMTV‐PyVT/HdhQ111/Q111 tumours (originating from the 3rd mammary gland, 14 weeks, n = 6 tumours per genotype, two independent immunoblotting) for the presence of ZO‐1, E‐cadherin, β‐catenin, vimentin and α‐tubulin. ZO‐1: ***p‐value = 0.0007; E‐cadherin: *p‐value = 0.0295; β‐catenin: *p‐value = 0.0238; vimentin: **p‐value =  C.Differential interfering contrast images of cells from MMTV‐PyVT/HdhQ7/Q7 and MMTV‐PyVT/HdhQ111/Q111 dissociated tumours.D.Immunoblotting of extracts from PyVT/HdhQ7/Q7 and PyVT/HdhQ111/Q111 cells as in (B).E.PyVT/HdhQ7/Q7 and PyVT/HdhQ111/Q111 cells are immunostained for endogenous E‐cadherin and β‐catenin. Cristovão Moreira Sousa et al. EMBO Mol Med. 2013;5: © as stated in the article, figure or figure legend

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