1. Survival of NZW rabbits following lethal B
Survival of NZW rabbits following lethal B. anthracis spore challenge and levofloxacin treatment with or without concomitant AVA vaccination (rabbit PEP study).
Survival of NZW rabbits following lethal B. anthracis spore challenge and levofloxacin treatment with or without concomitant AVA vaccination (rabbit PEP study). Rabbits were challenged via inhalation with aerosolized B. anthracis spores on day 0 and treated once daily for 7 days with levofloxacin at 50 mg/kg via oral gavage, starting at 6 to 12 h postchallenge; untreated controls were treated with WFI. Concomitantly, animals received two i.m. immunizations with AVA at 6 to 12 h postchallenge (day 1) and on day 8. Antibiotic-only controls received adjuvant alone (saline with 650 μg of aluminum hydroxide gel). Animals were monitored for morbidity and mortality for 30 days postchallenge. Overall group survival rates at the time of study termination are shown in parentheses. *, Survival rate was significantly greater than that in the control group (P < 0.004).
Boris Ionin et al. Clin. Vaccine Immunol. 2013; doi: /CVI