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Frances Balkwill, Kellie A. Charles, Alberto Mantovani  Cancer Cell 

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Presentation on theme: "Frances Balkwill, Kellie A. Charles, Alberto Mantovani  Cancer Cell "— Presentation transcript:

1 Smoldering and polarized inflammation in the initiation and promotion of malignant disease 
Frances Balkwill, Kellie A. Charles, Alberto Mantovani  Cancer Cell  Volume 7, Issue 3, Pages (March 2005) DOI: /j.ccr Copyright © 2005 Elsevier Inc. Terms and Conditions

2 Figure 1 Type II macrophages in the tumor microenvironment.
Mononuclear phagocytes recruited in chimeras polarize in an M2 direction in response to microenvironmental signals. M2 TAMs promote chimera progression, matrix remodeling, and angiogenesis, and divert and tame adaptive immunity. Cancer Cell 2005 7, DOI: ( /j.ccr ) Copyright © 2005 Elsevier Inc. Terms and Conditions

3 Figure 2 Mechanisms of inflammation-induced cancer
Wide blue arrows indicate the primary source of the inflammatory stimulus. Cancer Cell 2005 7, DOI: ( /j.ccr ) Copyright © 2005 Elsevier Inc. Terms and Conditions


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