1. Genetic Optimization of Liver Cancer Therapy: A Patient-Derived Primary Cancer Cell- Based Model 
Patricia Munoz-Garrido, Jesper B. Andersen 
Gastroenterology 
Volume 152, Issue 1, Pages (January 2017)
DOI: /j.gastro
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2. Figure 1
Overview of the patient-derived cell line-based model. The schematic illustrates (A) intertumor heterogeneity and phylogenetic tree modeling of each patient, (B) intratumor heterogeneity (ITH) in human HCC and the patient-derived primary cancer cell (PDPC) culture model. (C) Focusing on a particular case the authors report that drug response is strictly dependent according to the expression of FGF19 in each tumor clone. This highlights the need for combination therapy and essential requirement for integration of genomic data prior to therapeutic decisions.
Gastroenterology  , 19-21DOI: ( /j.gastro )
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