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Sustained Expression of Steroid Receptor Coactivator SRC-2/TIF-2 is Associated with Better Prognosis in Malignant Pleural Mesothelioma  Cormac J. Jennings,

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Presentation on theme: "Sustained Expression of Steroid Receptor Coactivator SRC-2/TIF-2 is Associated with Better Prognosis in Malignant Pleural Mesothelioma  Cormac J. Jennings,"— Presentation transcript:

1 Sustained Expression of Steroid Receptor Coactivator SRC-2/TIF-2 is Associated with Better Prognosis in Malignant Pleural Mesothelioma  Cormac J. Jennings, MPhil, Anthony O'Grady, PhD, Robert Cummins, PhD, Bruno Murer, MD, Mazen Al-Alawi, PhD, Stephen F. Madden, PhD, Luciano Mutti, MD, Brian J. Harvey, PhD, Warren Thomas, PhD, Elaine W. Kay, MD  Journal of Thoracic Oncology  Volume 7, Issue 1, Pages (January 2012) DOI: /JTO.0b013e31822f6544 Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Kaplan-Meier survival curves for malignant pleural mesothelioma subject survival discriminated by histological type (A) and gender (B). Journal of Thoracic Oncology 2012 7, DOI: ( /JTO.0b013e31822f6544) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Representative immunohistochemical staining (×200 magnification) TIF-2 (A–E) and ERβ (F–J) in normal pleural mesothelium (NM) and malignant pleural mesothelioma tumor tissue with Allred score (AS) values of 2, 4, 6, and 8. Journal of Thoracic Oncology 2012 7, DOI: ( /JTO.0b013e31822f6544) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 Kaplan-Meier survival curves for malignant pleural mesothelioma subject survival discriminated by high versus low/intermediate TIF-2 expression for the whole subject cohort (A), epithelioid cases only (B), and male subjects only (C). Journal of Thoracic Oncology 2012 7, DOI: ( /JTO.0b013e31822f6544) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

5 FIGURE 4 Kaplan-Meier survival curve for malignant pleural mesothelioma subject survival discriminated by positive versus negative/ERβ expression for the whole subject cohort. Journal of Thoracic Oncology 2012 7, DOI: ( /JTO.0b013e31822f6544) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

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