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Large cell neuroendocrine carcinoma of the lung: A clinicopathologic study of eighty- seven cases  Hidefumi Takei, MDa,b, Hisao Asamura, MDb, Arafumi Maeshima,

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Presentation on theme: "Large cell neuroendocrine carcinoma of the lung: A clinicopathologic study of eighty- seven cases  Hidefumi Takei, MDa,b, Hisao Asamura, MDb, Arafumi Maeshima,"— Presentation transcript:

1 Large cell neuroendocrine carcinoma of the lung: A clinicopathologic study of eighty- seven cases 
Hidefumi Takei, MDa,b, Hisao Asamura, MDb, Arafumi Maeshima, MDc, Kenji Suzuki, MDb, Haruhiko Kondo, MDb, Toshiro Niki, MDc, Tesshi Yamada, MDc, Ryosuke Tsuchiya, MDa,b, Yoshihiro Matsuno, MDa  The Journal of Thoracic and Cardiovascular Surgery  Volume 124, Issue 2, Pages (August 2002) DOI: /mtc Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

2 Fig. 1 A, Representative photomicrograph of LCNEC. Organoid pattern, palisading, and necrosis are shown. (Hematoxylin and eosin; original magnification 100×.) B, Tumor cells are large and polygonal with abundant and finely granular cytoplasm, easily discernible nucleoli in some cells. Note also rosette-like structures. (Hematoxylin and eosin; original magnification 400×.) The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

3 Fig. 2 Representative staining of chromogranin A in LCNEC cases: A, Focal; B, patchy; C, diffuse. (Immunostain; original magnification 400×.) The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

4 Fig. 3 Survival curves of patients with LCNEC (n = 87), other poorly differentiated NSCLCs (n = 426), LCC (n = 102), and SCLC (n = 31) for all stages. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

5 Fig. 4 Survival curves of 41 patients with LCNEC of stage I and 126 patients with other poorly differentiated NSCLCs of stage I (P =.003, log-rank test). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

6 Fig. 5 Survival curves of 41 patients with LCNEC of stage I and 29 patients of LCC of stage I (P =.03, log-rank test). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

7 Fig. 6 Survival curves of 41 patients with LCNEC of stage I and 9 patients with SCLC of stage I (P =.87, log-rank test). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

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