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Volume 149, Issue 2, Pages e8 (August 2015)

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Presentation on theme: "Volume 149, Issue 2, Pages e8 (August 2015)"— Presentation transcript:

1 Volume 149, Issue 2, Pages 398-406.e8 (August 2015)
Combining Data From Liver Disease Scoring Systems Better Predicts Outcomes of Patients With Alcoholic Hepatitis  Alexandre Louvet, Julien Labreuche, Florent Artru, Jérôme Boursier, Dong Joon Kim, John O’Grady, Eric Trépo, Pierre Nahon, Nathalie Ganne-Carrié, Sylvie Naveau, Emmanuel Diaz, Thierry Gustot, Guillaume Lassailly, Amélie Cannesson-Leroy, Valérie Canva- Delcambre, Sébastien Dharancy, Seung Ha Park, Christophe Moreno, Timothy R. Morgan, Alain Duhamel, Philippe Mathurin  Gastroenterology  Volume 149, Issue 2, Pages e8 (August 2015) DOI: /j.gastro Copyright © 2015 AGA Institute Terms and Conditions

2 Figure 1 Two- and 6-month overall mortality probability according to the joint-effect model combining the Lille model and Maddrey DF. +, hypothetical patient with a Maddrey DF at 56 at baseline and a Lille score at 0.45: 2-month mortality rate is 19.8% and 6-month mortality rate is 29.6%. Gastroenterology  , e8DOI: ( /j.gastro ) Copyright © 2015 AGA Institute Terms and Conditions

3 Figure 2 Two- and 6-month overall mortality probability according to the joint-effect model combining the Lille model and MELD score. +, hypothetical patient with a MELD score at 21 and a Lille score at 0.45: 2-month mortality rate is 15.3% and 6-month mortality rate is 23.7%. Gastroenterology  , e8DOI: ( /j.gastro ) Copyright © 2015 AGA Institute Terms and Conditions

4 Supplementary Figure 1 Study flowchart for the derivation sample. Primary analysis refers to the analysis of the joint effect of the Lille model with Maddrey DF on survival. Secondary analysis refers to the analysis of the joint effect of the Lille model with MELD score on survival. Gastroenterology  , e8DOI: ( /j.gastro ) Copyright © 2015 AGA Institute Terms and Conditions

5 Supplementary Figure 2 Study flowchart for validation sample. Primary analysis refers to the analysis of the joint effect of the Lille model with Maddrey DF on survival. Secondary analysis refers to the analysis of the joint effect of the Lille model with MELD score on survival. Gastroenterology  , e8DOI: ( /j.gastro ) Copyright © 2015 AGA Institute Terms and Conditions

6 Supplementary Figure 3 Diagnosis of linear functional form for the Lille model, Maddrey DF, MELD, and ABIC scores using Martingale residuals plots. There is a linear relationship between the log relative risk of death and each of the 4 scores. Gastroenterology  , e8DOI: ( /j.gastro ) Copyright © 2015 AGA Institute Terms and Conditions

7 Supplementary Figure 4 Two- and 6-month overall mortality probability according to the joint-effect model combining the Lille model and ABIC score. +, hypothetical patient with an ABIC score at 6.71 and a Lille score at 0.45: 2-month mortality rate is 13.4% and 6-month mortality rate is 20.6%; 6.71 corresponds to the lowest proposed cut-off value of the ABIC score. Gastroenterology  , e8DOI: ( /j.gastro ) Copyright © 2015 AGA Institute Terms and Conditions


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