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The Role of Cytotoxic Therapy with Hematopoietic Stem Cell Transplantation in the Therapy of Acute Myelogenous Leukemia in Adults: An Evidence-Based Review Denise M. Oliansky, Frederick Appelbaum, Peter A. Cassileth, Armand Keating, Jamie Kerr, Yago Nieto, Susan Stewart, Richard M. Stone, Martin S. Tallman, Philip L. McCarthy, Theresa Hahn Biology of Blood and Marrow Transplantation Volume 14, Issue 2, Pages (February 2008) DOI: /j.bbmt Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions
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Figure 1 Relative risk (RR) of relapse or death rate comparing autologous BMT with the control arm. (Reprinted with permission; [7].) Biology of Blood and Marrow Transplantation , DOI: ( /j.bbmt ) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions
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Figure 2 Forrest plot of the HRs and 95% CIs for OS. Study identifications are provided below. FEM and REM denote summary HRs by the fixed-effect and random-effect models. The varying sizes of the filled diamonds represent the weight for the fixed-effect model in the meta-analysis. A hazard ratio greater than unity means that allogeneic transplantation is superior to nonallogeneic transplantation. Study IDs: 1-1: Reiffers et al. [10]; 2-1: Keating et al., Br J Haematol. 1998;102: ; 3-1 to 3-6: Slovak et al. [116]; 4-1 to 4-5: Burnett et al. [20]; 5-1 to 5-4: Suciu et al. [30]. (Reprinted with permission; [18].) Biology of Blood and Marrow Transplantation , DOI: ( /j.bbmt ) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions
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Figure 3 Actuarial rates of DFS of patients with AML in first complete remission according to donor availability. (Reprinted with permission; [19].) Biology of Blood and Marrow Transplantation , DOI: ( /j.bbmt ) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions
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Figure 4 Adjusted probability of LFS of persons years old with AML in first remission in the IBMTR and GAMLCG databases. Numbers in parentheses indicate numbers of persons at risk at different intervals. (Reprinted with permission; [21].) Biology of Blood and Marrow Transplantation , DOI: ( /j.bbmt ) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions
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Figure 5 DFS from CR according to donor availability. The estimates of the 4-year DFS rates (±SE) for the donor group (dotted line) and the no donor group (solid line) are given. The 4-year cumulative incidence of relapse and of death in CR are given in italics at the right of the graph. N indicates the number of patients; O, observed number of events (relapse or death in first CR). P is determined by the log-rank test. (Reprinted with permission; [30].) Biology of Blood and Marrow Transplantation , DOI: ( /j.bbmt ) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions
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Figure 6 Actuarial LFS in autograft recipients with AML in CR1 treated with Bu/Cy (broken line) (n = 330) or Cy/TBI (solid line) (n = 330). The survival curves are not significantly different (P = .64). (Reprinted with permission; [77].) Biology of Blood and Marrow Transplantation , DOI: ( /j.bbmt ) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions
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Figure 7 Actuarial LFS in allograft recipients with AML in CR1 treated with Bu/Cy (n = 223) or Cy/TBI (n = 223). Survival curves are not significantly different (P = .63). (Reprinted with permission; [77].) Biology of Blood and Marrow Transplantation , DOI: ( /j.bbmt ) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions
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Figure 8 Unadjusted cumulative incidence of LFS for patients over 50 years of age with AML receiving myeloablative (MA) versus reduced intensity conditioning (RIC) prior to HLA-identical sibling HSCT. (Reprinted with permission; [87].) Biology of Blood and Marrow Transplantation , DOI: ( /j.bbmt ) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions
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