1. TUCAN (CARD8) Genetic Variants and Inflammatory Bowel Disease
Dermot P.B. McGovern, Helen Butler, Tariq Ahmad, Marta Paolucci, David A. van Heel, Kenichi Negoro, Pirro Hysi, Jiannis Ragoussis, Simon P.L. Travis, Lon R. Cardon, Derek P. Jewell 
Gastroenterology 
Volume 131, Issue 4, Pages (October 2006)
DOI: /j.gastro
Copyright © 2006 American Gastroenterological Association (AGA) Institute Terms and Conditions

2. Figure 1
Cartoon showing linkage disequilibrium pattern across TUCAN (created in Haploview). Values represent 100 × D′ values of linkage disequilibrium. The blank squares represent D′ values of 1.0. Three haplotypes are marked as predicted by Haploview (see Materials and Methods).
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2006 American Gastroenterological Association (AGA) Institute Terms and Conditions

3. Figure 2
Adaptation of Fagan’s nomogram29 showing the approximate relationship between pretest probabilities, likelihood ratios, and posttest probabilities. Pretest probabilities are estimated from the clinical picture or from population prevalence data. In this example, the pretest probabilities of 30%, 50% (see discussion), and 0.2% (approximate population prevalence of CD) have been chosen to illustrate the clinical utility of likelihood ratios. The nomogram shows how a positive likelihood ratio of approximately 8 (Table 4) can “convert” the pretest probabilities of 30%, 50%, and 0.2% to posttest probabilities of approximately 75%, 90%, and 1.7%, respectively. Similarly, a negative likelihood ratio of 0.2 converts pretest probabilities of 30% and 50% to posttest probabilities of approximately 8% and 17%.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2006 American Gastroenterological Association (AGA) Institute Terms and Conditions