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HAT Trick: p300, Small Molecule, Inhibitor

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Presentation on theme: "HAT Trick: p300, Small Molecule, Inhibitor"— Presentation transcript:

1 HAT Trick: p300, Small Molecule, Inhibitor
Melanie Ott, Eric Verdin  Chemistry & Biology  Volume 17, Issue 5, Pages (May 2010) DOI: /j.chembiol Copyright © 2010 Elsevier Ltd Terms and Conditions

2 Figure 1 p300 Regulation and Its Nonhistone Substrates
p300 autoacetylation enhances its acetyltransferase activity. The NAD-dependent sirtuin SIRT2 deacetylates p300 and inactivates it, while p300 acetylation of SIRT2 inhibits its deacetylase activity. Several nonhistone substrates of p300 and their possible therapeutic implications are shown. Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2010 Elsevier Ltd Terms and Conditions

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