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Comparison of antibiotic susceptibility patterns in Pseudomonas aeruginosa isolated from adult patients with cystic fibrosis (CF) with invasive Pseudomonas.

Published byFrida Klausen Modified over 5 years ago

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Presentation on theme: "Comparison of antibiotic susceptibility patterns in Pseudomonas aeruginosa isolated from adult patients with cystic fibrosis (CF) with invasive Pseudomonas."— Presentation transcript:

1 Comparison of antibiotic susceptibility patterns in Pseudomonas aeruginosa isolated from adult patients with cystic fibrosis (CF) with invasive Pseudomonas aeruginosa from non-CF patients  Priyanka Rao, John McCaughan, Mark McCalmont, Colin.E. Goldsmith, Valerie Hall, B. Cherie Millar, Mary-Ann McCann, Damian G. Downey, Jacqueline C. Rendall, J. Stuart Elborn, John E. Moore  Journal of Cystic Fibrosis  Volume 11, Issue 4, Pages (July 2012) DOI: /j.jcf Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

2 Fig. 1 Comparison of antibiotic susceptibility in eight antibiotic agents from CF-associated Pseudomonas aeruginosa and non-CF P. aeruginosa obtained from invasive blood culture material. P. aeruginosa from CF sputum (n=127 shaded bars) were compared with 123 isolates obtained from blood culture of patients without CF (unshaded bars). P. aeruginosa originating from CF sources were significantly more resistant to all classes of antibiotics tested, as well as for all individual examples of antibiotics with these classes of antibiotics. Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

3 Fig. 2 A Venn diagram showing association between antibiotic susceptibilities of CF-associated Pseudomonas aeruginosa within three classes of antibiotics, namely aminoglycosides (tobramycin), β-lactams (meropenem) and the fluoroquinolones (ciprofloxacin). Isolates were classified as being either susceptible (complete sensitivity) or non-susceptible (moderately resistance and fully resistant). Within the Venn diagram circles are 65 isolates representing varying degrees of antibiotic resistance, whilst there are 62 isolates outside the Venn diagram, representing the susceptible isolates. Together, these constitute the entire population of P. aeruginosa isolates examined in this study (i.e =127 isolates). Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

4 Fig. 3 Cluster analysis based on Euclidean distances relating antibiotic susceptibilities to 11 antibiotic agents amongst 127 isolates of CF-associated Pseudomonas aeruginosa. Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

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