Presentation is loading. Please wait.

Presentation is loading. Please wait.

A Sub-Type of Familial Pancreatic Cancer: Evidence and Implications of Loss-of- Function Polymorphisms in Indoleamine-2,3-Dioxygenase-2  Avinoam Nevler,

Published byゆき やすこ Modified over 5 years ago

Similar presentations

Presentation on theme: "A Sub-Type of Familial Pancreatic Cancer: Evidence and Implications of Loss-of- Function Polymorphisms in Indoleamine-2,3-Dioxygenase-2  Avinoam Nevler,"— Presentation transcript:

1 A Sub-Type of Familial Pancreatic Cancer: Evidence and Implications of Loss-of- Function Polymorphisms in Indoleamine-2,3-Dioxygenase-2  Avinoam Nevler, MD, Alexander J. Muller, PhD, Joseph A. Cozzitorto, BA, Austin Goetz, MD, Jordan M. Winter, MD, FACS, Theresa P. Yeo, PhD, MPH, MSN, Harish Lavu, MD, FACS, Charles J. Yeo, MD, FACS, George C. Prendergast, PhD, Jonathan R. Brody, PhD  Journal of the American College of Surgeons  Volume 226, Issue 4, Pages (April 2018) DOI: /j.jamcollsurg Copyright © 2018 The Authors Terms and Conditions

2 Figure 1 Representative chromatograms of direct sequencing of patient constitutional genomic DNA showing the 3 possible sequences of homozygous, heterozygous, or wild-type sequence: R248W polymorphism (left) and Y359STOP (right). Journal of the American College of Surgeons  , DOI: ( /j.jamcollsurg ) Copyright © 2018 The Authors Terms and Conditions

3 Figure 2 Functionally inactive indoleamine-2,3-dioxygenase-2 (IDO2) alleles are frequently found in familial pancreatic cancer (FPC) patients. (A) Prevalence of FPC in various Y359Stop genotypes (wild-type, heterozygous, and homozygous) in the entire Thomas Jefferson University Hospital (TJUH) cohort (FPCs and sporadic pancreatic ductal adenocarcinoma [PDA]). Spearman's correlation test (ρ = 0.229, p < 0.05). (B) Y359Stop genotype distribution in FPC as compared with CEU (Utah residents with northern and western European ancestry) control cases. chi-square test, 2 × 3 comparison, p = WT, wild type. (C) Rates of FPC in various R248W genotypes. Spearman's correlation test (ρ = 0.028, p = NS) in the entire TJUH cohort (FPCs and sporadic PDA). (D) R248W genotype distribution in FPC compared with CEU control cases. Chi-square test, 2 × 3 comparison, p = NS. Journal of the American College of Surgeons  , DOI: ( /j.jamcollsurg ) Copyright © 2018 The Authors Terms and Conditions

4 Figure 3 Indoleamine-2,3-dioxygenase-2 (IDO2) genotype variations in familial pancreatic cancer (FPC) compared with sporadic pancreatic ductal adenocarcinoma (PDA) cases and CEU (Utah residents with northern and western European ancestry) control cases. Chi-square/Fisher's exact comparisons. OR, odds ratio. Journal of the American College of Surgeons  , DOI: ( /j.jamcollsurg ) Copyright © 2018 The Authors Terms and Conditions

Download ppt "A Sub-Type of Familial Pancreatic Cancer: Evidence and Implications of Loss-of- Function Polymorphisms in Indoleamine-2,3-Dioxygenase-2  Avinoam Nevler,"

Similar presentations

Massive Bronchogenic Cyst Joseph B. Levin, BA, Chi Wan Koo, MD, Jessica S. Donington, MD Journal of Thoracic Oncology Volume 5, Issue 11, Pages 1862-1863.

Massive Bronchogenic Cyst Joseph B. Levin, BA, Chi Wan Koo, MD, Jessica S. Donington, MD Journal of Thoracic Oncology Volume 5, Issue 11, Pages
Physician-Owned Surgical Hospitals Outperform Other Hospitals in Medicare Value- Based Purchasing Program  Adriana G. Ramirez, MD, Margaret C. Tracci,

Physician-Owned Surgical Hospitals Outperform Other Hospitals in Medicare Value- Based Purchasing Program  Adriana G. Ramirez, MD, Margaret C. Tracci,
Surgeons Can Favorably Influence Career Choices and Goals for Students Interested in Careers in Medicine  Jonathan Hernandez, MD, Sam Al-Saadi, MD, Robert.

Surgeons Can Favorably Influence Career Choices and Goals for Students Interested in Careers in Medicine  Jonathan Hernandez, MD, Sam Al-Saadi, MD, Robert.
Comparative Efficacy of Bilateral Thoracoscopic Splanchnicectomy for Intractable Pain Secondary to Pancreatic Cancer vs Chronic Pancreatitis  Neal Bhutiani,

Comparative Efficacy of Bilateral Thoracoscopic Splanchnicectomy for Intractable Pain Secondary to Pancreatic Cancer vs Chronic Pancreatitis  Neal Bhutiani,
The Hartford Consensus: Survey of the Public and Healthcare Professionals on Active Shooter Events in Hospitals  Lenworth M. Jacobs, MD, MPH, FACS, Karyl.

The Hartford Consensus: Survey of the Public and Healthcare Professionals on Active Shooter Events in Hospitals  Lenworth M. Jacobs, MD, MPH, FACS, Karyl.
Transforming Hemoglobin Measurement in Trauma Patients: Noninvasive Spot Check Hemoglobin  Bellal Joseph, MD, FACS, Viraj Pandit, MD, Hassan Aziz, MD,

Transforming Hemoglobin Measurement in Trauma Patients: Noninvasive Spot Check Hemoglobin  Bellal Joseph, MD, FACS, Viraj Pandit, MD, Hassan Aziz, MD,
Lenworth M. Jacobs, MD, MPH, FACS, Karyl J

Lenworth M. Jacobs, MD, MPH, FACS, Karyl J
Development and Participant Assessment of a Practical Quality Improvement Educational Initiative for Surgical Residents  Morgan M. Sellers, BA, Kristi.

Development and Participant Assessment of a Practical Quality Improvement Educational Initiative for Surgical Residents  Morgan M. Sellers, BA, Kristi.
Trend in Volume of Urologic Prosthetic Surgery after Initiation of Prostate Cancer Survivorship Program  Alison M. Rasper, MD, Kara E. McAbee, MD, Marc.

Trend in Volume of Urologic Prosthetic Surgery after Initiation of Prostate Cancer Survivorship Program  Alison M. Rasper, MD, Kara E. McAbee, MD, Marc.
Transforming Hemoglobin Measurement in Trauma Patients: Noninvasive Spot Check Hemoglobin  Bellal Joseph, MD, FACS, Viraj Pandit, MD, Hassan Aziz, MD,

Transforming Hemoglobin Measurement in Trauma Patients: Noninvasive Spot Check Hemoglobin  Bellal Joseph, MD, FACS, Viraj Pandit, MD, Hassan Aziz, MD,
Simple Suturing Technique for Umbilical Dimple Wound after Single-Incision Laparoscopic Surgery  Yoichi Matsui, MD, PhD, Sohei Satoi, MD, PhD, FACS, Satoshi.

Simple Suturing Technique for Umbilical Dimple Wound after Single-Incision Laparoscopic Surgery  Yoichi Matsui, MD, PhD, Sohei Satoi, MD, PhD, FACS, Satoshi.
Malpractice Risk and Cost Are Significantly Reduced after Tort Reform

Malpractice Risk and Cost Are Significantly Reduced after Tort Reform
Exploring the Relationship Between Stereotype Perception and Residents' Well-Being  Arghavan Salles, MD, PhD, Claudia M. Mueller, PhD, MD, FACS, Geoffrey.

Exploring the Relationship Between Stereotype Perception and Residents' Well-Being  Arghavan Salles, MD, PhD, Claudia M. Mueller, PhD, MD, FACS, Geoffrey.
The Diverse Surgeons Initiative: An Effective Method for Increasing the Number of Under-represented Minorities in Academic Surgery  Paris D. Butler, MD,

The Diverse Surgeons Initiative: An Effective Method for Increasing the Number of Under-represented Minorities in Academic Surgery  Paris D. Butler, MD,
Michael T. Kassin, MD, Rachel M. Owen, MD, Sebastian D

Michael T. Kassin, MD, Rachel M. Owen, MD, Sebastian D
Simple Suturing Technique for Umbilical Dimple Wound after Single-Incision Laparoscopic Surgery  Yoichi Matsui, MD, PhD, Sohei Satoi, MD, PhD, FACS, Satoshi.

Simple Suturing Technique for Umbilical Dimple Wound after Single-Incision Laparoscopic Surgery  Yoichi Matsui, MD, PhD, Sohei Satoi, MD, PhD, FACS, Satoshi.
Introduction of Mechanical Sphincter Augmentation for Gastroesophageal Reflux Disease into Practice: Early Clinical Outcomes and Keys to Successful Adoption 

Introduction of Mechanical Sphincter Augmentation for Gastroesophageal Reflux Disease into Practice: Early Clinical Outcomes and Keys to Successful Adoption 
Validation of New Readmission Data in the American College of Surgeons National Surgical Quality Improvement Program  Morgan M. Sellers, BA, Ryan P. Merkow,

Validation of New Readmission Data in the American College of Surgeons National Surgical Quality Improvement Program  Morgan M. Sellers, BA, Ryan P. Merkow,
Are Surgeons Being Paid Fairly by Medicaid

Are Surgeons Being Paid Fairly by Medicaid
Motorcycle Helmets Associated with Lower Risk of Cervical Spine Injury: Debunking the Myth  Joseph G. Crompton, MD, Curt Bone, BS, Tolulope Oyetunji,

Motorcycle Helmets Associated with Lower Risk of Cervical Spine Injury: Debunking the Myth  Joseph G. Crompton, MD, Curt Bone, BS, Tolulope Oyetunji,

Similar presentations

Ads by Google