1. N-Glycosidic bond formation with PRPP
N-Glycosidic bond formation with PRPP. PRPP and atoms of the products derived from PRPP are shown in red.
N-Glycosidic bond formation with PRPP. PRPP and atoms of the products derived from PRPP are shown in red. Each reaction produces an N-glycosidic 5′-phosphoribosyl compound and PPi. The reaction with quinolinate also produces carbon dioxide. The compounds a to e are products of de novo reactions: a, 5-phosphoribosyl 1-amine; b, orotidine 5′-monophosphate; c, 5′-phosphoribosylnicotinate; d, 5′-phosphoribosyl-ATP; e, 5′-phosphoribosylanthranilate. The compounds f to k are products of salvage reactions: f, AMP; g, IMP; h, XMP; i, GMP; j, UMP; k, 5′-phosphoribosylnicotinate.
Bjarne Hove-Jensen et al. Microbiol. Mol. Biol. Rev. 2017; doi: /MMBR