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Nasal epithelium as a proxy for bronchial epithelium for smoking-induced gene expression and expression Quantitative Trait Loci  Kai Imkamp, MD, Marijn.

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Presentation on theme: "Nasal epithelium as a proxy for bronchial epithelium for smoking-induced gene expression and expression Quantitative Trait Loci  Kai Imkamp, MD, Marijn."— Presentation transcript:

1 Nasal epithelium as a proxy for bronchial epithelium for smoking-induced gene expression and expression Quantitative Trait Loci  Kai Imkamp, MD, Marijn Berg, Cornelis J. Vermeulen, PhD, Irene H. Heijink, PhD, Victor Guryev, PhD, Huib A.M. Kerstjens, MD, PhD, Gerard H. Koppelman, MD, PhD, Maarten van den Berge, MD, PhD, Alen Faiz, PhD  Journal of Allergy and Clinical Immunology  Volume 142, Issue 1, Pages e15 (July 2018) DOI: /j.jaci Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Comparison between nasal and bronchial epithelial brushes. A, PCA. B, Heatmap of genes altered by smoking in both nasal and bronchial biopsies. C, Correlation of eQTL beta's from bronchial- (red) and nasal (blue)-specific eQTLs and concordant eQTLs (green). eQTL analysis of (D) GSDMB and (E) SSH2 in nasal and bronchial brushes. The unadjusted mean and 95% CI are plotted. The genotypes are shown on the x-axis, and the log2 microarray intensity is shown on the y-axis. PCA, Principal-component analysis. Journal of Allergy and Clinical Immunology  , e15DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig E1 Scatter plot of fold changes between smokers and nonsmokers in nasal and bronchial brushes. Red points indicate genes increased in the bronchus compared with the nasal, and blue points indicate genes decreased in the bronchus compared with the nasal. LFC, Log2 fold change. Journal of Allergy and Clinical Immunology  , e15DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig E2 Genes with high expression: Correlation of eQTL beta's from bronchial and nasal brushings. Journal of Allergy and Clinical Immunology  , e15DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig E3 Genes with moderate expression: Correlation of eQTL beta's from bronchial and nasal brushings. Journal of Allergy and Clinical Immunology  , e15DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig E4 Genes with low expression: Correlation of eQTL beta's from bronchial and nasal brushings. Journal of Allergy and Clinical Immunology  , e15DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Fig E5 Box plots for all significant eQTLs from both nasal and bronchial expression profiles (A-Q). EST, Estimate. Journal of Allergy and Clinical Immunology  , e15DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

8 Fig E5 Box plots for all significant eQTLs from both nasal and bronchial expression profiles (A-Q). EST, Estimate. Journal of Allergy and Clinical Immunology  , e15DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

9 Fig E5 Box plots for all significant eQTLs from both nasal and bronchial expression profiles (A-Q). EST, Estimate. Journal of Allergy and Clinical Immunology  , e15DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

10 Fig E5 Box plots for all significant eQTLs from both nasal and bronchial expression profiles (A-Q). EST, Estimate. Journal of Allergy and Clinical Immunology  , e15DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

11 Fig E5 Box plots for all significant eQTLs from both nasal and bronchial expression profiles (A-Q). EST, Estimate. Journal of Allergy and Clinical Immunology  , e15DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

12 Fig E5 Box plots for all significant eQTLs from both nasal and bronchial expression profiles (A-Q). EST, Estimate. Journal of Allergy and Clinical Immunology  , e15DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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