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This Month in Gastroenterology

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Presentation on theme: "This Month in Gastroenterology"— Presentation transcript:

1 This Month in Gastroenterology
Jan Tack, John M. Carethers  Gastroenterology  Volume 137, Issue 6, Pages (December 2009) DOI: /j.gastro Copyright © 2009 AGA Institute Terms and Conditions

2 Figure 1 Logistic regression plot of odds rations (95% confidence intervals) for factors determining in-hospital mortality in the case-controlled analysis. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions

3 Figure 2 Probability of developing solid organ malignancy after liver transplantation (OLT). ALD, alcohol-related liver disease; PSC, primary sclerosing cholangitis. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions

4 Figure 3 Box plots of the distribution of values for ratios between thrombin generation with/without thrombomodulin for healthy subjects, patients with cirrhosis of protein C congenital deficiency. Thrombin generation has been assessed as endogenous thrombin potential (ETP). Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions

5 Figure 4 Model of HOXB1 and HOXB3 suppression by the retinoic acid (RA) mediator miR-10a in pancreatic cancer metastasis. RA stimulates dimerization of RAR/RXR retinoic receptors, which bind to retinoic acid response elements (RAREs) in the regulatory region of miR-10a and trigger increased miR-10a expression. Suppression of HOXB1 and HOXB3 by miR-10a then promotes invasion and metastatic behavior (upper panel). RA stimulation, miR-10a overexpression or suppression of HOXB1 and HOXB3 (by siRNAs) are equally sufficient to confer metastatic behavior to these cells. Transcriptional repression of miR-10a by a selective RARα inhibitor (Ro ) releases the suppression of HOXB1 and HOXB3 and prevents invasiveness and metastatic behavior (lower panel). The inhibitory function of Ro can be overruled by suppression of HOXB1 and HOXB3 with siRNAs. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions


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