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Resisting resistance: new chemical strategies for battling superbugs

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Presentation on theme: "Resisting resistance: new chemical strategies for battling superbugs"— Presentation transcript:

1 Resisting resistance: new chemical strategies for battling superbugs
Gerard D Wright  Chemistry & Biology  Volume 7, Issue 6, Pages R127-R132 (June 2000) DOI: /S (00)

2 Figure 1 Structure and general mechanism of action of medically important β-lactamase inhibitors. Chemistry & Biology 2000 7, R127-R132DOI: ( /S (00) )

3 Figure 2 Structures of compunds referred to in the text that inhibit antibiotic resistance mechanisms or have antimicrobial activity. Chemistry & Biology 2000 7, R127-R132DOI: ( /S (00) )

4 Figure 3 Proposed inactivation of aminoglycoside 3′-kinases by 2′-nitro aminoglycoside derivatives. Chemistry & Biology 2000 7, R127-R132DOI: ( /S (00) )

5 Figure 4 Self regeneration of 3′-ketoaminoglycosides following phosphorylation by aminoglycoside 3′-kinases. Chemistry & Biology 2000 7, R127-R132DOI: ( /S (00) )

6 Figure 5 Light inactivation of a β-lactam antibiotic.
Chemistry & Biology 2000 7, R127-R132DOI: ( /S (00) )


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