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Bioactive Peptides from Libraries

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Presentation on theme: "Bioactive Peptides from Libraries"— Presentation transcript:

1 Bioactive Peptides from Libraries
Chiara Falciani, Luisa Lozzi, Alessandro Pini, Luisa Bracci  Chemistry & Biology  Volume 12, Issue 4, Pages (April 2005) DOI: /j.chembiol Copyright © 2005 Elsevier Ltd Terms and Conditions

2 Figure 1 Portion Mixing Method for Synthetic Combinatorial Libraries
The resin is divided and recombined at every coupling step. Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2005 Elsevier Ltd Terms and Conditions

3 Figure 2 Descriptive Model of Iterative Process and Positional Scanning Deconvolution Approaches See text for details. Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2005 Elsevier Ltd Terms and Conditions

4 Figure 3 Dynamic Libraries See text for details.
Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2005 Elsevier Ltd Terms and Conditions

5 Figure 4 Example of Libraries from Libraries See text for details.
Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2005 Elsevier Ltd Terms and Conditions

6 Figure 5 Peptides Displayed on M13 Phage Surface as Fusion to the Amino Terminus of pVIII (A) or pIII (B) Coat Proteins Proportions are not observed in this picture. Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2005 Elsevier Ltd Terms and Conditions

7 Figure 6 Examples of Constrained Structures See text for details.
Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2005 Elsevier Ltd Terms and Conditions

8 Figure 7 Schematic Representation of the Similarity of MAP to Phage Displayed (A) and Membrane Bound (B) Peptides See text for details. Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2005 Elsevier Ltd Terms and Conditions


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