1. A correlative study for POP of target-based drugs using gene expression cDNA array
Pharmacology Division,
National Cancer Center Research Institute
Kazuto Nishio

2. 775 genes Clustering Q-Q-plot Post(Day 8） / Pre(Day 1）
Clustering and Q-Q plot analysis of gene alteration in PBL samples of target based drug-treated patients
Clustering
775
genes
Q-Q-plot
Post(Day 8） / Pre(Day 1） 8 7 6 5
-log P 4 3 2 1 1 2 3 4 5 6 7 8
Savage Score Up
Down
Zero
Missing

3. Principal component analysis
-0.6
-0.4
-0.2
0.2
0.4
0.6
PRIN 1
PRIN 3
400 mg b.i.d.
cluster
300 mg b.i.d.
200 mg b.i.d.
Principal component analysis
3D Elgenvector plot
200 mg b.i.d.
300 mg b.i.d.
PRIN 3
-0.8
0.1
0.2
0.3
0.4
0.5 40 20
PRIN 1
-20
400 mg b.i.d.
-40
Signaｌ
-60
-80 20 40 60 80