1. Cyclosporine suppresses rat hepatic cytochrome P450 in a time-dependent manner 
Lane J. Brunner, William M. Bennett, Dennis R. Koop 
Kidney International 
Volume 54, Issue 1, Pages (July 1998)
DOI: /j x
Copyright © 1998 International Society of Nephrology Terms and Conditions

2. Figure 1
Markers of renal function in rats following treatment with either cyclosporine (•) or vehicle (○) as outlined in the Methods section. Abbreviations are: SCr, serum creatinine; CCr, creatinine clearance; FEK, fractional excretion of potassium; UOsm, urine osmolality. Data are expressed as mean ± standard error of four rats in each group.
Kidney International  , DOI: ( /j x)
Copyright © 1998 International Society of Nephrology Terms and Conditions

3. Figure 2
Hepatic microsomal P450 3A2 and 2C11 protein levels and P450-dependent testosterone hydroxylation produced by rats following treatment with either cyclosporine (•) or vehicle (○) as outlined in the Methods section. Microsomal protein band density is indicated in arbitrary units. 6β-OHT and 2α-OHT represent the in vitro microsomal production of 6β-hydroxytestosterone and 2α-hydroxytestosterone, respectively. Catalytic activity is expressed as nmol product/min/mg protein. Data are expressed as mean ± standard error of four rats in each group.
Kidney International  , DOI: ( /j x)
Copyright © 1998 International Society of Nephrology Terms and Conditions

4. Figure 3
Steroid 5α-reductase activity in the production of androstanedione by hepatic microsomes from rats following treatment with either cyclosporine (•) or vehicle (○) as outlined in the Methods section. Catalytic activity is expressed as nmol product/min/mg protein. Data are expressed as mean ± standard error of four rats in each group.
Kidney International  , DOI: ( /j x)
Copyright © 1998 International Society of Nephrology Terms and Conditions

5. Figure 4
Whole blood cyclosporine trough levels in rats administered cyclosporine 15mg/kg/day by subcutaneous injection for up to 28days and then following drug discontinuation for an additional 15days. Data are expressed as mean ± standard error of four rats in each group.
Kidney International  , DOI: ( /j x)
Copyright © 1998 International Society of Nephrology Terms and Conditions