1. Nat. Rev. Neurol. doi:10.1038/nrneurol.2015.197
Figure 3 Hemivagotomy prevents α-synuclein accumulation in the ipsilateral DMNV
Figure 3 | Hemivagotomy prevents α-synuclein accumulation in the ipsilateral DMNV. Confocal images (single plane) of DMNV sections from mice, stained with anti-α-synuclein (green) and anti-ChAT antibodies (red) and DAPI (blue). Scale bar 60 nm. a | The DMNV of an untreated mouse. b | The DMNV of a mouse that was treated with rotenone for 4 months but did not undergo hemivagotomy. c | The DMNV of a mouse that was treated with rotenone for 4 months and underwent hemivagotomy. Rotenone markedly increased the amount of α-synuclein in ChAT+ neurons on the intact (right) side relative to the vagotomized side (left). Abbreviations: A, anterior; ChAT, choline acetyltransferase; DAPI, 4,6-diamino-2-phenylindole; DMNV, dorsal motor nucleus of the vagus; L, left; P, posterior; R, right. Permission obtained from Nature Publishing Group © Pan-Montojo, F. et al. Sci. Rep. 2, 898 (2012).
Permission obtained from Nature Publishing Group © Pan-Montojo, F. et al. Sci. Rep. 2, 898 (2012)
Klingelhoefer, L. & Reichmann, H. (2015) Pathogenesis of Parkinson disease—the gut–brain axis and environmental factors
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